联合检测血清CA153,CEA和TSGF在乳腺癌中的应用

目的探讨乳腺癌患者血清CA153,CEA和TSGF联合检测及其临床意义。方法ELISA法测定158例乳腺肿瘤患者5、1例乳腺良性疾病患者及43例健康体检者血清CA153,CEA水平,光电比色法检测血清TSGF水平。结果初治、治疗无效及复发转移患者的血清CA153,CEA和TSGF水平均明显高于乳腺良性疾病、健康体检者和治疗显效组的水平;血清CA153、CEA和TSGF联合检测的敏感性及准确性高于任意二项联合检测及单项检测,而特异性以CA153为最高。结论检测血清CA153,CEA和TSGF水平对乳腺癌的疗效、预后判断及监控复发和转移有较高的临床价值,联合检测血清CA153,CEA和TSGF水平可以提高诊断的敏感性和准确性。

Value of combined determinations of serum CA153, CEA and TSGF in patients with breast carcinoma

Objective To determine the clinicad significance of serum tumor markers of CA153,CEA and TSGF in patients with breast carcinoma.Methods serum CA153,CEA levels were determined by ELISA and TSGF was measured by spectrophotometry in 158 patients with breast carcinomas,51 patients with benign breast diseases and 43 healthy persons.Results the level of serum CA153,CEA and TSGF in the initiated,nonrespondars and relapsed or metastases of breast carcinomas were profoundly higher than those in benign bteasr diseased,healthy persons and breast carcinoma responders,repectively.Combined determination of three kinds of the serum tumor markers CAI 53,CEA and TSGF was of more sisitive and specific than any other combination of two or the single one.Conclusion the determination of serum tumor markers CA153,CEA and TSGF might bc useful parameters for assessing of response to treatmet and predicting prognosis of breast carcinoma.