| 脂多糖缺失所致多黏菌素耐药的鲍曼不动杆菌研究进展 |
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| 引用本文： | 卞星晨,刘笑芬 张菁,陈代杰. 脂多糖缺失所致多黏菌素耐药的鲍曼不动杆菌研究进展[J]. 中国抗生素杂志, 2019, 44(2): 186-190 |
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| 作者姓名： | 卞星晨 刘笑芬 张菁 陈代杰 |
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| 作者单位： | 上海师范大学生命与环境科学学院;复旦大学附属华山医院抗生素研究所;上海交通大学药学院 |
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| 基金项目： | 国家自然科学基金(No.81628015和No.81503114) |
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| 摘 要： | 多黏菌素E(黏菌素)和多黏菌素B已成为治疗广泛耐药的革兰阴性菌感染的"最后一条防线"。但是,近年来有关鲍曼不动杆菌对多黏菌素的耐药性时有报道,尤其是有关脂多糖(LPS)缺失或修饰导致多黏菌素耐药的鲍曼不动杆菌各方面性质的改变,如细菌适应性下降,外膜合成相关基因表达增加,对其他抗生素敏感性提高,机械强度降低,细菌毒力下降,固有免疫因子水平变化等。本文将对近年来有关LPS缺失引起的鲍曼不动杆菌各方面性质变化的研究进行简要的综述。
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| 关 键 词： | 鲍曼不动杆菌 多黏菌素 脂多糖 耐药 |
Progress in colistin resistant Acinetobacter baumannii associated with lipopolysaccharide loss |
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| Bian Xing-chen,Liu Xiao-fen,Zhang Jing,Chen Dai-jie. Progress in colistin resistant Acinetobacter baumannii associated with lipopolysaccharide loss[J]. Chinese Journal of Antibiotics, 2019, 44(2): 186-190 |
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| Authors: | Bian Xing-chen Liu Xiao-fen Zhang Jing Chen Dai-jie |
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| Affiliation: | (College of Life and Environmental Sciences,Shanghai Normal University Shanghai 200234;Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai 200040;School of Pharmacy,Shanghai Jiaotong University,Shanghai 200240) |
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| Abstract: | Polymyxin E (colistin) and polymyxin B have become the last resort to deal with extensively-resistant Gram negative bacteria. With the increase use of these drugs, polymyxin-resistance has become a serious problem. LPS loss or modification that related to colistin resistance can lead to property changes of Acinetobacter baumannii, such as decrease of bacteria fitness, virulence and mechanical strength, increase of gene expression associated with outer membrane synthesis and sensitivity to antibiotics and some other changes of innate immune system. This review is mainly about changes in colistin resistant Acinetobacter baumannii associated with LPS loss. |
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| Keywords: | Acinetobacter baumannii Colistin Lipopolysaccharide Resistance |
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