加米霉素注射液在猪体内残留消除研究

目的为了探讨自制加米霉素注射液在猪体内的残留消除规律,验证休药期。方法本试验将选取体质健康的28头猪,随机分为2组,对照组4头,试验组24头。试验组猪按6mg/kgB.W.单次肌注射加米霉素,对照组不做处理。在注射后第0.5、7、14、21、28和35d时,采集肌肉、肝脏、肾脏、皮脂及注射部位肌肉。UPLC-MS/MS法测定组织中的加米霉素残留量,并用WT1.4软件计算休药期。结果加米霉素在猪肌肉、肝脏、肾脏、皮脂和注射部位肌肉的休药期分别是9.68、11.62、17.37、24.35和26.75d。结论为保证兽药使用安全、食品安全,推荐加米霉素注射液在猪的休药期为27d。

Residue depletion study of gamithromycin injection in swine

In order to explore the residual elimination characteristics of gamithromycin injection in swine, theduration of withdrawal was verified. The experiment selected 32 healthy swine to be randomly divided into two groups,two in the control group and 30 in the treatment group. Swine were single muscle injected with 6mg/kg B.W in thetreatment group. The control group did not deal with it. On 0.5, 7, 14, 21, 28 and 35d after the injection, muscle,liver, kidney, sebum, and injection site muscles were collected. The concentrations of residues of gamithromycin intissues were determined using UPLC-MS/MS, and WT1.4 software was used to calculate the withdrawal time. Theresults showed that, the withdrawal periods of gamithromycin in swine muscle, liver, kidney, sebum, and injectionsite muscles were 9.68, 11.62, 17.37, 24.35 and 26.75d. To ensure the safe use of veterinary drugs and food safety, therecommended time for the withdrawal of gamithromycin injection is 27d in