氧化应激对胎盘生命的影响

氧化应激不仅是氧化剂的产生与抗氧化剂防御系统之间的不平衡状态,也是众多细胞功能障碍和组织损伤的原因。氧化应激相关因子在多种疾病中发挥重要作用,通过多种途径调节细胞内环境稳定,维持细胞存活。近年研究发现,氧化应激与相关的氧化损伤是导致多种疾病的主要因素,氧化应激相关指标在妊娠特有疾病(如子痫前期、胎儿生长受限)孕妇的血清及胎盘滋养细胞中高度表达。氧化应激同时与肿瘤、高血压等多种慢性疾病有关,与多种疾病的发生、发展密切相关。氧化应激作为妊娠期特有疾病的"共同通路"被深入研究,其中氧化应激对胎盘功能的影响备受关注。分析与总结胎盘在不同缺氧状态下与妊娠相关疾病的关系,探索氧化应激相关因子是否具有预测作用,为围生期相关疾病的预防及诊疗提供新方向、新思路。

Effects of Oxidative Stress on Placental Life

Oxidative stress is not only the imbalance between the generation of oxidants and the antioxidant defense system, but also the cause of various cell dysfunction and tissue damage. Oxidative stress related factors play an important role in a variety of diseases. It adjusts the homeostasis of intracellular environment through a variety of pathways. In recent years, studies have found that oxidative stress and the related oxidative damage is the main factor leading to many diseases. Indicators related to oxidative stress in pregnancy-specific diseases such as preeclampsia pregnancy and fetal growth restriction are highly expressed in maternal serum and trophoblast cells. Meanwhile, oxidative stress is involved in the pathogenesis of various chronic disorders such as cancer and hypertension. Oxidative stress, as a common pathway of pregnancy-specific diseases, has been deeply studied, among which the effect of oxidative stress on placental function has attracted much attention. This paper analyzes and summarizes the relationship between placenta and pregnancy-related diseases under different hypoxic conditions, to explore whether oxidative stress related factors have predictive effect for pregnancy-related disease prevention and treatment.