肿瘤坏死因子相关诱导凋亡配体及其受体与宫颈癌的关系

宫颈癌是女性生殖系统最常见的恶性肿瘤之一,其发生率呈明显上升且年轻化的趋势。目前,除传统手术及放化疗方式治疗恶性肿瘤外,肿瘤生物学治疗方法的地位逐渐提高。肿瘤坏死因子相关诱导凋亡配体(TRAIL)是近年新发现的肿瘤坏死因子超家族成员之一,与细胞膜表面的特异性受体结合,通过活化天冬氨酸蛋白水解酶或线粒体依赖途径选择性地诱导肿瘤细胞凋亡而正常细胞可凋亡逃逸,这种性质使其被认为是肿瘤治疗中极有潜力的靶向治疗因子,具有十分重要的临床价值。研究发现,TRAIL及其受体在宫颈癌组织中存在异常表达,并成为近年研究的热点。综述TRAIL及其受体的结构、生物学功能,在宫颈癌上皮细胞中的表达情况及其在宫颈癌中的研究进展。

The Relationship between Tumor Necrosis Factor Related Apoptosis-Inducing Ligand and Its Receptors and Cervical Cancer

Cervical cancer is one of the most common malignancies of the female reproductive system. At present，in addition that operation, radiotherapy and chemotherapy were used to treat the cancer, oncobiology therapeutic methods are getting more and more important. Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) is one of the newly discovered tumor necrosis factor super family members. It binds to specific receptors on the surface of the cytomembrane. Through activation of caspase or mitochondrial dependent pathway, tumor cells were selectively induced to apoptosis and normal cells could escape. This property makes it considered as a potential target therapeutic factor in oncotherapy. It has extremely important clinical value. Studies found that TRAIL and its receptors were abnormally expressed in cervical cancer tissue, which has become the research hotspot in recent years. Therefore, this article reviews the structure and biological function of TRAIL and TRAIL receptors, their expression in cervical cancer epithelial cells and the research progress.