弥漫大B细胞淋巴瘤患者血清IL-24及IL-6浓度检测 的临床意义

目的：探讨弥漫大B细胞淋巴瘤（DLBCL）患者外周血清IL-24及IL-6的浓度及其临床意义。方法：收集43例DLBCL患者和33例正常对照人群外周血血清，ELISA法检测IL-24及IL-6的浓度，分析血清IL-24及IL-6浓度与患者临床病理指标之间的关系；并计算患者的国际预后指数（IPI）。结果：与正常对照组[IL-24浓度为（58.32±11.81）μg/mL，IL-6为（24.63±7.73）μg/mL]相比，DLBCL患者血清IL-24浓度[（42.18±8.48）μg/mL]明显降低（P<0.01），而IL-6浓度[（45.29±12.71）μg/mL]明显升高（P<0.01），且二者浓度呈明显负相关（r=-0.414，P<0.05）；同时血清IL-24及IL-6浓度与患者临床分期、肿瘤细胞侵犯骨髓状态及IPI均密切相关（P<0.01），而与患者年龄及性别均无明显相关关系（P>0.05）。发生骨髓转移组患者血清中IL-24较正常对照组和未转移组均明显降低（P<0.01），而IL-6浓度明显升高（P<0.01）；同时随着骨髓转移程度的增加，该趋势更为明显。IPI指数>2的患者，外周血IL-24浓度较IPI指数<2的患者明显降低，而IL-6浓度明显升高（P<0.01）。结论：DLBCL患者血清IL-24浓度较低及IL-6浓度较高可能是患者临床症状较重，预后较差的预测指标。血清IL-24及IL-6浓度测定可作为DLBCL的辅助诊断及监测指标，为临床治疗提供科学依据。

Clinical values of serum IL-24 and IL-6 concentrations for patients with diffuse large B-cell lymphoma

OBJECTIVE:To investigate the significance of IL-24 and IL-6 concentrations in serum of patients with Diffuse large B-cell lymphoma (DLBCL). METHODS:Concentrations of serum IL-24 and IL-6 were detected using the ELISA assay. The relationship between the concentrations and the clinicopathological parameters in 43 cases of DLBCL patients was analyzed. RESULTS:Compared with the control patients,the concentrations of IL-24 and IL-6:(58.32 ±11.81) and (24.63 ±7.73) μg/mL, respectively, and the IL-24 concentration:(42.18 ±8.48) μg/mL in the DLBCL patients were significantly lower, whereas the IL-6 concentration:(45.29±12.71) μg/mL was significantly higher (P<0.01). Furthermore,the concentrations of IL-24 was significantly lower,while the IL-6 was higher in the serum of the patients who had bone marrow invasion than those without the invasion (P<0.01). The similar results were also shown in the patients with the high IPI scores (P<0.01). These findings suggest that the low IL-24 and high IL-6 concentrations may be predictors for poor clinical status and prognosis of DLBCL patients. CONCLUSION:Detection of the serum IL-24 and IL-6 concentrations may be useful as auxiliary diagnosis for improved clinical therapy in DLBCL.