| 替考拉宁在特殊人群中药动学研究进展 |
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| 引用本文： | 李渊源,柴栋 王瑾 王睿 蔡芸. 替考拉宁在特殊人群中药动学研究进展[J]. 中国抗生素杂志, 2019, 44(6): 654-660 |
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| 作者姓名： | 李渊源 柴栋 王瑾 王睿 蔡芸 |
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| 作者单位： | 解放军医学院;解放军总医院药物临床研究中心;解放军总医院临床药学中心 |
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| 基金项目： | 十三五重大新药创制国家科技重大专项(No.2018ZX09201013);国家自然科学基金(No.81770004) |
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| 摘 要： | 替考拉宁是临床治疗耐甲氧西林金黄色葡萄球菌等耐药革兰阳性菌感染的首选药物之一。本文分别对近年来替考拉宁在老年人、儿童,重症感染、肾功能不全、低白蛋白血症、严重烧伤、血液肿瘤患者等特殊人群中的药动学研宂进展进行综述,考察特殊病理生理状态对其疗效和安全性的影响,为临床合理用药提供参考。
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| 关 键 词： | 替考拉宁:药动学 给药剂量 治疗药物浓度 综述 |
Advances in research on pharmacokinetics of teicoplanin in special populations |
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| Li Yuan-yuan,Chai Dong,Wang Jin,Wang Rui,Cai Yun. Advances in research on pharmacokinetics of teicoplanin in special populations[J]. Chinese Journal of Antibiotics, 2019, 44(6): 654-660 |
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| Authors: | Li Yuan-yuan Chai Dong Wang Jin Wang Rui Cai Yun |
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| Affiliation: | (Medical School of Chinese People's Liberation Army,Beijing 100853;Medicine Clinical Research Center,Chinese People'sLiberation Army General Hospital,Beijing 100853;Clinical Pharmacy Center,Chinese People's Liberation Army General Hospital,Beijing 100853) |
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| Abstract: | Teicoplanin is one of the first optional drugs in the clinical treatment of drug-resistant Gram-positive bacteria infections (such as methicillin-resistant Staphylococcus aureus, etc.). This paper reviewed recent advances in pharmacokinetics of teicoplanin in special populations of the elderly, children, severe infections, renal dysfunction, hypoalbuminemia, severe burns and hematological malignancies and investigated the effect of special pathophysiological states on their efficacy ansd safety, in order to provide reference on the rational use of |
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| Keywords: | Teicoplanin Pharmacokinetics Administration dosage Therapeutic drug concentration Review |
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