多囊卵巢综合征伴胰岛素抵抗对生育影响的研究进展

多囊卵巢综合征(PCOS)是育龄妇女常见的内分泌性疾病,跨越了妇女生命的全过程,以高胰岛素血症、高雄激素血症和(或)无排卵为特征,目前病因尚不明确,然而胰岛素抵抗(IR)是PCOS患者常见的代谢紊乱性疾病。由此产生的高胰岛素血症可导致激素水平改变、卵泡生长受限、子宫内膜容受性改变,增加流产率或导致不孕等,同时可增加妊娠合并症的发病率,甚至让患者产生焦虑、抑郁等心理问题,因此PCOS伴IR越来越受到人们的重视。阐述PCOS伴IR对生育影响的研究进展。

Fertility of Patients with Polycystic Ovary Syndrome Combined with Insulin Resistance

Polycystic ovary syndrome (PCOS), a common endocrine disease in women of pregnancy age, is characterized by hyperinsulinemia, hyperandrogenism and/or anovulation. It spans the whole process of women's life. However, the etiology of PCOS is still unclear. Insulin resistance (IR) is one of the common metabolic disorders in patients with PCOS, in which hyperinsulinemia can lead to the changes in hormone levels, follicular growth restriction, endometrial receptivity, and increased abortion or infertility rates. The increased incidence of pregnancy complications, even anxiety, depression and other psychological problems, could be related with IR. PCOS combined with IR has attracted more and more attention in reproductive medicine.