宫颈原始神经外胚层肿瘤一例及文献复习

为探讨宫颈原始神经外胚层肿瘤[primitive neuroectodermal tumor，PNET；又称尤文氏肉瘤（Ewing sarcoma）]的组织起源、临床特征及诊治进展，提高对该种特殊类型宫颈恶性肿瘤的认识，回顾性分析2016年1月吉林大学第二医院收治的1例PNET患者，该患者体检发现宫颈肿物，无特殊临床表现，经手术病理及免疫组织化学（免疫组化）染色确诊，免疫组化显示人白细胞分化抗原99（cluster of differentiation 99，CD99）、波形蛋白（vimentin，VIM）阳性。提示该类肿瘤极为罕见，生长迅速、恶性程度高、侵袭性强、死亡率高、预后极差，目前尚无标准治疗方案，诊断主要依据病理、免疫组化及细胞遗传学。

Cervical Primitive Neuroectodermal Tumor: A Case Report and Literature Review

To investigate the genesis, clinical characteristics, diagnosis and treatment progress of cervical primitive neuroectodermal tumor (PNET), also called Ewing sarcoma, improve the understandings of this special type of cervical malignancies. A case of cervical PNET, at the Second Hospital of Jilin University in January 2016, was analyzed retrospectively. The tumor was found accidently in a routine examination with no clinical manifestations. The patient was finally confirmed by surgical pathologic examination and immunohistochemical staining. Immunohistochemistry was positive for CD99 and vimentin. Cervix PNET is a extremely rare and aggressively invasive tumor with high malignancy and mortality. The diagnosis depends on pathology, immunohistology and cytogenetics and there is no consensus on treatment so far.