急性缺血性卒中睡眠障碍与执行功能障碍的相关性分析

目的 探究急性缺血性卒中睡眠障碍与执行功能障碍的相关性。 

Relationship between Sleep Disorders and Executive Dysfunction in Patients with Acute Ischemic Stroke

Objective To explore the relationship between sleep disorders and executive dysfunction in
patients with acute ischemic stroke (AIS).
Methods A total of 105 consective AIS patients in Department of Neurology of Southwest Medical
University Affiliated Hospital from May 2017 to November 2017 were collected. Based on the
Pittsburgh sleep quality index (PSQI) at 2 weeks from onset, all patients were divided into two
groups: sleep disorder group and non-sleep disorder group. The executive function of all patients
were evaluated by Stroop test, 2-back task, clock-drawing test (CDT) and trail making test (TMT).
The relationship between sleep disorders and executive dysfunction in AIS patients was investigated.
Results (1) The results of Stroop test: under the conflict conditions, the response time in sleep
disorder group (344.31±23.16) ms] was longer than that in non-sleep disorder group (283.92±29.20)ms] (P <0.001); the interference amount of response time in sleep disorder group (61.58±16.10) ms]
was longer than that in non-sleep disorder group (51.04±21.16) ms] (P =0.005). The interference
amount of correct number in sleep disorder group 3.00 (2.00-5.00)] was lower than that in non-sleep
disorder 6.00 (4.75-8.00)] (P <0.001). (2) The results of the 2-back task: the incorrect rate in sleep
disorder group 50% (46%-52%)] was higher than that in non-sleep disorder group 19% (17%-20%)]
(Z =8.771, P <0.001). (3) The results of TMT: the completion time of line A test in sleep disorder group
84.00 (79.00-89.00) s] was longer than that in non-sleep disorder group 65.00 (61.75-69.00) s]; the
completion time of line B test in sleep disorder group 184.00 (173.00-199.00) s] was longer than
that in non-sleep disorder group 130.00 (107.00-147.50) s] (both P <0.001). The interference amount
of the line test in sleep disorder group (101.91±20.31) s] was significantly longer than that in nonsleep
disorder group (64.34±29.62) s] (P <0.001). (4) In CDT, the finish time in sleep disorder group
3.00 (3.00-3.00) s] was longer than that in non-sleep disorder group 2 (2.00-3.00) s] (Z =6.260,
P <0.001). (5) PSQI score was not correlated with the interference amount of response time in Stroop
test, while negatively correlated with the interference amount of correct number (r =-0.424, P <0.001),
had significant positive correlation with the incorrect rate in 2-back task (r =0.750, P <0.001), and had
positive correlation with the interference amount of TMT (r =0.503, P <0.001) as well as the CDT time
(r =0.503, P <0.001).
Conclusions AIS patients with sleep disorders are more likely to have executive function
impairment compared to those without sleep disorders. The more serious sleep disorders are, the
more worse executive function will be.