间充质干细胞分泌因子调节氧化应激的作用

衰老和疾病发生发展大多伴随氧化应激水平升高,包括多囊卵巢综合征、卵巢储备减少和卵巢早衰等生殖内分泌疾病。干细胞治疗已应用于多种疾病或其临床研究,而间充质干细胞（MSC）相对于胚胎干细胞和诱导多能干细胞具有明显的优势,如应用于子宫内膜粘连、多囊卵巢综合征和卵巢早衰临床治疗的研究。MSC分泌的众多细胞因子对组织细胞内氧化应激具有调节作用。研究发现,白细胞介素6（IL-6）和脑源性神经营养因子（BDNF）能激活核因子E2相关因子2（Nrf2）通路降低氧化应激水平。综述MSC分泌因子的抗氧化应激作用,阐述其可能的细胞内作用机制,为探讨MSC临床应用提供新思路。

Regulation of the Cytokins from Mesenchymal Stem Cells on Oxidative Stress

The pathophysiological process of diseases is mostly accompanied by the elevated level of oxidative stress, including those reproductive endocrine diseases such as polycystic ovary syndrome, decrease ovarian reserve and premature ovarian failure. Stem cells have been used in the cell therapy or clinical trials of many diseases including endometrial adhesion, polycystic ovary syndrome and premature ovarian failure, in which mesenchymal stem cells (MSC) have distinct advantages over embryonic stem cells (ESC) and induced pluripotent stem cells (iPS). Numerous cytokines secreted by MSC have a regulatory effect on oxidative stress in tissues and cells. It has been found that interleukin-6 (IL-6) and brain-derived neurotrophic factor (BDNF) decrease the level of oxidative stress by the activated Nrf2 pathway. In this paper, the anti-oxidative stress of the cytokins from mesenchymal stem cells is reviewed, as well as its possible intracellular mechanism, so as to provide a new idea for the further clinical trial of the cell therapy with mesenchymal stem cells.