CHAP抗生酶数据库的构建及其信息分析

目的建立CHAP抗生酶数据库,对已知的CHAP抗生酶信息进行收集整理,为研究其功能机制,和设计研发新型CHAP抗生酶提供帮助。方法收集公共数据库和科学文献中的CHAP抗生酶信息,使用UniProtKB,InterPro,PDB,GO和BioPerl进行信息关联和信息注释;使用Apache,MySQL,PHP,Perl和jQuery构建数据库及WEB页面。结果构建了基于WAMP架构的CHAP抗生酶数据库(http://biotechlab.fudan.edu.cn/database/chap),包含来自于263种来源的1572种CHAP抗生酶,WEB界面提供浏览、搜索和统计信息等功能,允许用户以自定义的搜索标准快速获取数据,并对CHAP抗生酶的序列、结构、来源、功能、物化性质等信息进行分析。结论本研究建立的CHAP抗生酶数据库作为抗生酶研究的一个独特工具,具有多种潜在的应用,为进行CHAP抗生酶研究的研究者提供了一个极有用的研究平台。

Construction and information analysis of CHAP enzybiotic database

Objective To establish a database of CHAP enzybiotics, we collected and analyzed the known information of CHAP enzybiotics. It will help researchers to study its functional mechanisms and to design and develop novel CHAP enzybiotics. Methods We collected CHAP enzybiotics information from public databases and scientific literatures, and used UniProtKB, InterPro, PDB, GO, and BioPerl for information correlation and annotation. We used Apache, MySQL, PHP, Perl, and jQuery to build databases and web pages. Results We constructed a database of CHAP enzybiotics (http://biotechlab.fudan.edu.cn/database/chap) on WAMP platform. The CHAP database contains 1,572 CHAP enzybiotics from 263 sources. The Web interface provides functions such as browsing, searching, and statistical information, allowing users to quickly access data based on defined search criteria and to analyze the sequence, structure, source, function, and materialization properties of CHAP enzybiotics. Conclusion As a unique tool for enzybiotics research, the CHAP enzybiotics database has a variety of potential applications, and provides a very useful research tool for researchers to conduct CHAP enzybiotics