Acute leukemia with two cell populations of lymphoblasts and monoblasts |
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| Authors: | T Ueda K Kita D Kagawa S Tamori S Ando M Sasada Y Yoshida H Uchino T Nakamura |
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| Affiliation: | 1. Department of Medicine, Faculty of Medicine, Kyoto University, Sakyo, Kyoto 606, Japan;2. Department of Medicine, Fukui Medical School, Matsuoka, Fukui, 910-11, Japan |
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| Abstract: | A 46-year-old man had acute leukemia with two cell populations of lymphoblasts and monoblasts (L1 and M5-b in FAB classification, respectively), which were characterized by morphological, cytochemical and cell marker studies. At the time of diagnosis about 80% blasts were terminal deoxynucleotidyl transferase (TdT) positive lymphoid cells, while the rest were TdT negative monocytoid cells. After induction chemotherapy of vindesine and prednisolone for 15 days, almost all blasts were TdT negative monocytoid cells. Therefore, an additional course of the chemotherapy with the protocol for acute nonlymphocytic leukemia was given and one month later the patient achieved complete remission. |
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| Keywords: | Mixed leukemia acute lymphocytic leukemia acute monocytic leukemia cell surface marker terminal deoxynucleotidyl transferase Correspondence to: Takanori Ueda, First Department of Medicine, Faculty of Medicine, Kyoto University, Sakyo, Kyoto 606, Japan. |
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