Circulating leptin and insulin in obese patients with and without type 2 diabetes mellitus: Relation to ghrelin and oxidative stress |
| |
| Affiliation: | 1. Department of Physiology, Faculty of Medicine, Assiut University, P.O. Box 71526, Assiut, Egypt;2. Department of Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt;3. Department of Rheumatology and Rehabilitation, Faculty of Medicine, Assiut University, Assiut, Egypt;4. Faculty of Medicine, Sohag University, Sohag, Egypt;1. Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China;2. Hepatobiliary Research Institute of North Sichuan Medical College, Nanchong, China;2. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA;1. Rheumatology & Rehabilitation Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt;2. Radiodiagnosis Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt;3. Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt;4. Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt;1. Faculty of Chemistry, Bu-Ali Sina University, Hamadan, Iran;2. Faculty of Chemistry, Kharazmi (Tarbiat Moallem) University, P.O. Box 15719-14911, Tehran, Iran;3. Quality Control Laboratory, ARA Quality Research Co., Tehran, Iran;1. Metabolic Bone Unit, Endocrinology Division (RETICEF), Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain;2. RETICEF, Instituto de Salud Carlos III, Spain;3. Proteomic Research Service, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain;4. Hospital del Mar-IMIM-UAB, Department of Internal Medicine, Barcelona, Spain;5. Hospital Universitario Marqués Valdecilla, Department of Internal Medicine, Santander, Spain;6. Osteoporosis Research Group. Universidad de Las Palmas de Gran Canaria. Las Palmas de Gran Canaria, Spain;7. Fundación Jiménez Díaz, Department of Internal Medicine, Madrid, Spain;8. Hospital Universitario Río Ortega, Department of Internal Medicine, Valladolid, Spain;9. Hospital Virgen Macarena. Department of Internal Medicine, Sevilla, Spain;10. Hospital La Paz, Department of Rheumatology, Madrid, Spain;11. Hospital Universitario Quirón, Department of Endocrinology, Madrid, Spain;12. CETIR Medical Centre, Barcelona, Spain;13. Trabeculae, Ourense, Spain |
| |
| Abstract: | AimThis case control study aimed to investigate relationship between appetite hormones (ghrelin and leptin) and body mass index (BMI), insulin and oxidative stress in simple obese and type 2 diabetes (T2DM) obese patients.MethodsThirty healthy controls; 30 simple obese and 30 T2DM obese patients were enrolled. Demographic and clinical data of all participants were reported. Serum levels of fasting blood glucose (FBG), postprandial blood glucose (PBG), lipid peroxide (LPO) and nitric oxide (NO) were measured by chemical methods while, insulin, leptin and ghrelin by ELISA kits.ResultsSerum levels of insulin, leptin, LPO were significantly higher while, ghrelin was significantly lower in simple obese and obese patients with diabetes versus controls. Insulin resistance was found in 76.67% simple obese and 93.33% obese patients with diabetes. Ghrelin showed a positive correlation with PBG in controls; but negative correlation with BMI in simple obese and with NO in obese patients with diabetes. Positive correlations were found between LPO and FBG, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and between leptin and FBG in obese patients with diabetes.ConclusionsOur results suggested that hyperinsulinemia and hyperleptinemia may be most important mechanisms in decreasing ghrelin and inducing oxidative stress in simple obese and T2DM obese patients. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
