| LC/MS/MS法测定人血浆中头孢克肟含量 |
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| 引用本文： | 李海霞,任进民,闫随朝,赵曦,李环,高娜.LC/MS/MS法测定人血浆中头孢克肟含量[J].中国抗生素杂志,2011,36(9):680-684. |
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| 作者姓名： | 李海霞 任进民 闫随朝 赵曦 李环 高娜 |
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| 作者单位： | 1. 石药集团药物研究院,石家庄,050051
2. 河北医科大学第二医院,石家庄,050000 |
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| 基金项目： | 石药集团新型药物制剂及工艺技术平台建设科技部"十一五"重大新药创制 |
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| 摘 要： | 目的 建立人血浆中头孢克肟的LC/MS/MS法.方法 血浆样品经蛋白沉淀提取,采用C8色谱柱分析,以乙腈:水:甲酸(40:60:0.5,v/v/v)为流动相,三重四级杆质谱检测器,正离子多反应监测模式(MRM),监测离子分别为:m/z 454.3→m/z 285.2(头孢克肟),m/z 282.2→m/z 212.2(...
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| 关 键 词： | 头孢克肟 LC/MS/MS 药代动力学 血药浓度 |
Sensitive liquid chromatography-tandem mass spectrometry method for the determination of cefixime in human plasma |
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| Li Hai-xia,Ren Jin-min,Yan Sui-chao,Zhao Yi,Li Huan,Gao Na.Sensitive liquid chromatography-tandem mass spectrometry method for the determination of cefixime in human plasma[J].Chinese Journal of Antibiotics,2011,36(9):680-684. |
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| Authors: | Li Hai-xia Ren Jin-min Yan Sui-chao Zhao Yi Li Huan Gao Na |
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| Institution: | Li Hai-xia1,Ren Jin-min2,Yan Sui-chao1,Yang Han-yu1,ZhaoYi1,Li Huan1 and Gao Na1(1 Pharmaceutical Academe of Shijiazhuang Pharmaceutical Group,Shijiazhuang 050051,2 The Second Hospital of Hebei Medical University,Shijiazhuang 050000) |
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| Abstract: | Objective To establish a high performance 1iquid chromatographic-tandem mass spectrometric(LC/MS/MS) method for the determination of cefixime in human plasma.Methods Plasma sample,prepared using protein precipitation method,was separated on a ZORBAX Eclipse XDB-C8 column.The mobile phase consisted of acetonitrile: water: formic acid(40: 60: 0.5,v/v/v) and was at a flow rat of 0.6mL/min.MS/MS detection in multiple reactions monitoring(MRM) mode using positive electrospray ionization as the ionization source ... |
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| Keywords: | Cefixime LC/MS/MS Pharmacokinetics Plasma concentration |
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