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| GSTM1和GSTT1基因多态性与抗结核药物性肝损害的关系 | |
| 引用本文： | 朱冬林,席云,吴雪琼.GSTM1和GSTT1基因多态性与抗结核药物性肝损害的关系[J].中国抗生素杂志,2011,36(11). |
| 作者姓名： | 朱冬林 席云 吴雪琼 |
| 作者单位： | 1. 中山大学附属第三医院检验科,广州510630;解放军第309医院全军结核病研究所,北京100091 2. 中山大学附属第三医院检验科,广州,510630 3. 解放军第309医院全军结核病研究所,北京,100091 |
| 基金项目： | “重大新药创制”科技重大专项资助项目，北京市科技计划研发攻关类科研基金 |
| 摘 要： | 目的 探讨汉族人群谷胱甘肽S转移酶M1(GSTMl)和T1(GSTT1)基因多态性与抗结核药物性肝损害(ATDLI)易感性的关系.方法 回顾性分析抗结核治疗后发生肝损害的结核病患者228例(病例组)及未发生肝损害的结核病患者300例(对照组),应用多重PCR技术检测其GSTM1和GSTT1基因多态性.结果 病例组与对照组GSTM1基因缺失型频率分别为58.3％和50.7％,差异无统计学意义(OR=1.363,95％CI=0.963～1.929); GSTT1基因缺失型频率分别为45.2％和49.3％,差异也无统计学意义.联合分析也未发现两种基因在抗结核药物性肝损害发生中具有协同作用.结论 汉族人群GSTM1和GSTT1基因多态性与抗结核药物性肝损害的发生无关. |
| 关 键 词： | GSTM1 GSTT1 结核 肝损害 基因多态性 |
Relationship between genetic polymorphisms of GSTM1, GSTT1 and the susceptibility to antituberculosis drug-induced liver injury |
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| Zhu Dong-lin,Xi Yun,Wu Xue-qiong.Relationship between genetic polymorphisms of GSTM1, GSTT1 and the susceptibility to antituberculosis drug-induced liver injury[J].Chinese Journal of Antibiotics,2011,36(11). | |
| Authors: | Zhu Dong-lin Xi Yun Wu Xue-qiong |
| Institution: | Zhu Dong-lin1,2,Xi Yun1 and Wu Xue-qiong2(1 The Third Affiliated Hospital Of Sun Yat-sen University,Guangzhou 510630,2 Institute of Tuberculosis Research,the 309th hospital of Chinese PLA,Beijing 100091) |
| Abstract: | Objective To investigate the relationship between the genetic polymorphisms of glutathione S-transferase M1,T1(GSTM1,GSTT1) and the susceptibility of antituberculosis drug-induced hepatotoxicity(ATDLI) in the tuberculosis patients of Chinese Han population.Methods Genetic polymorphisms of GSTM1,GSTT1 were analyzed in tuberculosis patients treated with or without hepatotoxicity after antituberculosis drug using multiple PCR method.Resultes The frequencies of GSTM1 null genotype were 58.3% in the ATDLI patien... |
| Keywords: | GSTM1 GSTT1 Tuberculosis Liver injury Genetic polymorphism |
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