| 非酒精性脂肪性肝病与代谢综合征 |
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| 引用本文： | 高鑫. 非酒精性脂肪性肝病与代谢综合征[J]. 中国实用内科杂志, 2011, 0(9) |
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| 作者姓名： | 高鑫 |
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| 作者单位： | 复旦大学附属中山医院内分泌科; |
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| 摘 要： | 非酒精性脂肪性肝病(NAFLD)事实上是一个肝脏脂肪性病变的疾病谱,包括单纯性脂肪肝、非酒精性脂肪性肝炎(NASH)、肝纤维化或肝硬化、肝衰竭,甚至部分患者发生肝细胞性肝癌。NAFLD与代谢综合征(MS)密切伴随,并认为是代谢综合征的肝脏表现。胰岛素抵抗可能是二者共同的发病基础。NAFLD已经成为MS、2型糖尿病(T2DM)和心血管疾病(CVD)的重要的独立预测因子,NAFLD成为T2DM和CVD高危人群,因此早期诊断和早期干预NAFLD对预防T2DM和CVD具有重要意义。
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| 关 键 词： | 非酒精性脂肪性肝病 代谢综合征 胰岛素抵抗 2型糖尿病 心血管疾病 |
Nonalcoholic fatty liver disease and metabolic syndrome |
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| GAO Xin. Nonalcoholic fatty liver disease and metabolic syndrome[J]. Chinese Journal of Practical Internal Medicine, 2011, 0(9) |
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| Authors: | GAO Xin |
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| Affiliation: | GAO Xin.Department of Endocrinlolgy and Metabolic Disease,Zhongshan Hospital,Fudan University,Shanghai 200032,China |
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| Abstract: | Nonalcoholic fatty liver disease(NAFLD)comprises a disease spectrum which includes variable degrees of simple steatosis nonalcoholic steatohepatitis(NASH) and cirrhosis even liver failure and patocellular carcinoma.NAFLD can be considered the hepatic manifestation of the metabolic syndrome and is an independent predictor of type 2 diabetes(T2DM) and cardiovascular disease(CVD).Insulin resistance is the pathogenetic link between the metabolic syndrome and fat accumulation in the liver.Patients with NAFLD are... |
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| Keywords: | NAFLD metabolic Syndrome insulin resistance type 2 diabetes cardiovascular disease |
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