| 莫西沙星与左氧氟沙星治疗AECOPD的对比研究 |
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| 引用本文： | 周凤丽,黄静,李洪涛,张文先,朱家馨,张天托. 莫西沙星与左氧氟沙星治疗AECOPD的对比研究[J]. 中国抗生素杂志, 2011, 36(7) |
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| 作者姓名： | 周凤丽 黄静 李洪涛 张文先 朱家馨 张天托 |
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| 作者单位： | 中山大学附属第三医院呼吸科,广州,510630 |
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| 摘 要： | 目的 观察莫西沙星注射液治疗慢性阻塞性肺疾病急性发作(AECOPD)的疗效、副作用和具体用药方法。方法 收集住院的AECOPD患者113例，随机分成两组，分别以莫西沙星和左氧氟沙星(对照组)治疗，比较两组治疗后的疗效、细菌清除率及对预后指标(FEV1、呼吸困难、6min步行距离)的改善率及药物副作用；同时将莫西沙星治疗组随机分为持续静脉滴注组和静滴加口服序贯治疗组，比较两组治疗后的疗效、细菌清除率及对预后指标(FEV1、呼吸困难、6min步行距离)的改善率。结果 莫西沙星治疗组的临床有效率(77.78％)、细菌清除率(81.48％)及对三项预后指标的改善率(82.54％、73.02％、69.84％)均高于左氧氟沙星组，而药物副作用发生率两组相当。莫西沙星持续治疗组与序贯治疗组比较，临床有效率、细菌清除率及对三项预后指标的改善率均无明显差异。结论 莫西沙星用于治疗AECOPD优于左氧氟沙星，且持续静滴给药治疗AECOPD与序贯给药比较无优势，从经济学角度，应推荐序贯给药治疗。
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| 关 键 词： | 慢性阻塞性肺疾病 急性发作期 莫西沙星 左氧氟沙星 疗效 |
A comparative study of moxifloxacin and levofloxacin in treating AECOPD |
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| Zhou Feng-Li,Huang Jing,Li Hong-Tao,Zhang Wen-xian,Zhang Jia-xin,Zhang Tian-tuo. A comparative study of moxifloxacin and levofloxacin in treating AECOPD[J]. Chinese Journal of Antibiotics, 2011, 36(7) |
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| Authors: | Zhou Feng-Li Huang Jing Li Hong-Tao Zhang Wen-xian Zhang Jia-xin Zhang Tian-tuo |
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| Affiliation: | Zhou Feng-Li,Huang Jing,Li Hong-Tao,Zhang Wen-xian,Zhang Jia-xin and Zhang Tian-tuo(Department of Respiratory Medicine,the Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510630) |
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| Abstract: | Objective To observe the curative effects and side effects and administration of moxifloxacin injection when used to treat acute explosion chronic obstructive pulmonary disease(AECOPD).Methods 113 hospitalized patients of AECOPD were collected and randomizedly divided into two groups and were treated with moxifloxacin or levofloxacin respectivly.The efficacy rates,bacteriums eradication rates and the side effects of two groups were compared.And the improvement rates of FEV1 or walking distance of 6min or dy... |
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| Keywords: | Chronic obstructive pulmonary diseases Acute episode Moxifloxacin Levofloxacin Curative effect |
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