| 多重耐药鲍曼不动杆菌16S rRNA甲基化酶研究进展 |
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| 引用本文： | 刘振茹,凌保东.多重耐药鲍曼不动杆菌16S rRNA甲基化酶研究进展[J].中国抗生素杂志,2011,36(10). |
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| 作者姓名： | 刘振茹 凌保东 |
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| 作者单位： | 川北医学院药物研究所,药理学教研室,南充637007 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 氨基糖苷类抗生素在治疗鲍曼不动杆菌引起的感染中起着重要的作用.而鲍曼不动杆菌对该类抗生素的耐药机制主要包括产氨基糖苷修饰酶,外膜孔蛋白表达缺失,药物外排泵的表达和核糖体结合位点的改变等.质粒介导的16S rRNA甲基化酶是近年在多重耐药鲍曼不动杆菌中发现的一种新的耐药机制,可导致对氨基糖苷类抗生素的高水平耐药.本文就细菌rRNA的修饰作用、16S rRNA甲基化酶的发现、耐药与传播机制、耐药菌的流行、多重耐药鲍曼不动杆菌16S rRNA甲基化酶基因的研究进展等方面作一综述.
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| 关 键 词： | 多重耐药 鲍曼不动杆菌 氨基糖苷类抗生素 16S rRNA甲基化酶 |
Advances in studying 16S rRNA methylation enzymes in multiple drug-resistant Acinetobacter baumannii |
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| Liu Zhen-ru,Ling Bao-Dong.Advances in studying 16S rRNA methylation enzymes in multiple drug-resistant Acinetobacter baumannii[J].Chinese Journal of Antibiotics,2011,36(10). |
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| Authors: | Liu Zhen-ru Ling Bao-Dong |
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| Institution: | Liu Zhen-ru and Ling Bao-Dong (Institute of Materia Medica and Department of Pharmacology,North Sichuan Medical College,Nanchong 637007) |
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| Abstract: | Aminoglycoside antibiotics play an important role in the treatment of infections caused by Acinetobacter baumannii.The mechanisms of resistance to this class of antibiotics include mainly the production of aminoglycoside-modifying enzymes,the lack or reduction of expression of certain outer membrane proteins,the increased expression of active drug efflux pumps and the alterations of the ribosome-binding sites.The involvement of 16S rRNA methylation enzymes encoded by plasmids belongs to a newly-identified d... |
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| Keywords: | Multidrug resistance Acinetobacter baumanni Aminoglycoside antibiotics 16S rRNA methylation enzymes |
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