| 2007-2009年金黄色葡萄球菌对万古霉素MIC值变化的研究 |
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| 引用本文： | 张光艳,卓超,黎晓强.2007-2009年金黄色葡萄球菌对万古霉素MIC值变化的研究[J].中国抗生素杂志,2011,36(9). |
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| 作者姓名： | 张光艳 卓超 黎晓强 |
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| 作者单位： | 重庆医科大学附属第一医院,重庆,400016 |
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| 摘 要： | 目的 逐年分析金黄色葡萄球菌对万古霉素、替考拉宁及利奈唑胺的MIC值变化,评估是否存在万古霉素MIC漂移.方法 收集我院2007-2009年临床分离的金黄色葡萄球菌菌株,头孢西丁纸片法确认MRSA,琼脂稀释法测定MRSA与MSSA菌株对万古霉素、替考拉宁、利奈唑胺及头孢西丁的最低抑菌浓度(MIC),计算MIC50,MIC90,MIC几何均值,敏感率及耐药率.结果 共收集金黄色葡萄球菌菌株184株,这3年的MRSA检出率分别为38.8%、46.7%和53.3%,呈逐年增高的趋势(P<0.005).万古霉素、替考拉宁及利奈唑胺对所有菌株均敏感.MRSA对万古霉素MIC几何均值为1.052、1.06和1.069μg/mL,呈逐年上升趋势(P<0.001),MIC≥1μg/mL菌株比例为68.4%、82.9%和91.6%,呈逐年增高的趋势(P<0.005).利奈唑胺对MRSA菌株几何均值为1.037、1.02和1.266μg/mL,无渐进性上升趋势(P>0.05).替考拉宁对MRSA菌株几何均值为0.747、0.714和0.971μg/mL,无渐进性上升趋势(P>0.05).MRSA对万古霉素的MIC几何均值高于MSSA组,差异具有统计学意义(P<0.01).结论 我院2007-2009年临床分离株MRSA检出率逐年增高,MRSA对万古霉素的MIC几何均值高于MSSA菌株,MRSA的MIC几何均值渐年上升,MIC≥1μg/mL菌株比例逐年增高,存在万古霉素MIC漂移趋势.
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| 关 键 词： | 金黄色葡萄球菌 万古霉素 MIC漂移 药物耐受性 |
Vancomycin MIC shift in clinical Staphylococcus aureus isolates from 2007 to 2009 |
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| Zhang Guang-yan,Zhuo Chao,Li Xiao-qiang.Vancomycin MIC shift in clinical Staphylococcus aureus isolates from 2007 to 2009[J].Chinese Journal of Antibiotics,2011,36(9). |
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| Authors: | Zhang Guang-yan Zhuo Chao Li Xiao-qiang |
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| Institution: | Zhang Guang-yan,Zhuo Chao and Li Xiao-qiang(the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016) |
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| Abstract: | Objective To assess whether Staphylococcus aureus vancomycin MIC creep of the first affiliated hospital of Chongqing Medical University occurred over the 3 year period.Additionally,MIC trends were evaluated for oxacillin,linezolid and teicoplanin.Methods From 2007 to 2009,the S.aureus strains were 184 isolates,selected for MRSA by Kirby-Bauer disk diffusion method with cefoxitin.MIC of vancomycin against S.aureus was determined by agar dilution test.The reported MIC result was used.MIC50,MIC90 and geometric... |
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| Keywords: | Staphylococcus aureus Vancomycin Creep Drug tolerance |
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