| 尿激酶型纤溶酶原激活剂及其抑制剂在舌鳞癌中的表达及意义 |
| |
| 引用本文： | 王秋旭,王天祥,刘维贤. 尿激酶型纤溶酶原激活剂及其抑制剂在舌鳞癌中的表达及意义[J]. 中国口腔颌面外科杂志, 2011, 9(3): 223-226 |
| |
| 作者姓名： | 王秋旭 王天祥 刘维贤 |
| |
| 作者单位： | 1. 中国医科大学附属盛京医院,口腔科,辽宁,沈阳,110004
2. 黑龙江省大庆油田总医院,口腔科,黑龙江,大庆,163001 |
| |
| 摘 要： | 目的:研究尿激酶型纤溶酶原激活剂(uPA)及其抑制剂(PAI-1)在舌鳞癌(TSCC)中的表达及其与临床病理参数的关系.方法:应用链霉卵白素-生物素复合体方法检测uPA及PAI-1在74例TSCC组织和15例癌旁正常黏膜中的表达.以SPSS10.0软件包对数据进行统计学处理,Kappa一致性法分析uPA和PAI-1表达...
|
| 关 键 词： | 尿激酶型纤溶酶原激活剂 舌肿瘤 鳞状细胞癌 免疫组织化学 |
Expressions and clinical significance of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) in tongue squamous cell carcinoma |
| |
| WANG Qiu-xu,WANG Tian-xiang,LIU Wei-xian. Expressions and clinical significance of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) in tongue squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2011, 9(3): 223-226 |
| |
| Authors: | WANG Qiu-xu WANG Tian-xiang LIU Wei-xian |
| |
| Affiliation: | 1.Department of Oral and Maxillofacial Surgery,Shengjing Hospital,China Medical University.Shenyang 110004,Liaoning Province;2.Department of Oral and Maxillofacial Surgery,Daqing Ail Field Hospital.Daqing 163001,Heilongjiang Province,China) |
| |
| Abstract: | PURPOSE： To study the expressions and clinical significance of urokinase-type plasminogen activator（uPA） and its inhibitor（PAI-1） in tongue squamous cell carcinoma（TSCC）.METHODS： The expression of uPA and PAI-1 at protein level was examined in 74 TSCC and 15 normal peripheral tissues around cancer（as control） by strep avidin-biotin complex（SABC） immunohistochemical assay.SPSS10.0 software package was used to analyze the correlation of uPA and PAI-1 expression and related clinicopathological parameters.RESULTS： The rates of the positive expression in TSCC of uPA and PAI-1 were 71.6%（53/74） and 75.7%（56/74）,respectively.There was significant correlation between the level of uPA expression and TNM stage or cervical lymph node status,between the level of PAI-1 expression and T stage cervical lymph node status.Pathological grade was not significantly related to the level of uPA or PAI-1 expression.TSCC cases with positive expression of uPA and PAI-1 revealed significantly higher tendency to cervical lymph node metastasis than those with negative expression of uPA and PAI-1（P0.05）.CONCLUSIONS： The expression of uPA and PAI-1 are increased in TSCC.uPA and PAI-1 may contribute significantly to TSCC invasion and metastasis. |
| |
| Keywords: | Urokinase-type plasminogen activator Tongue neoplasm Squamous cell cancer Immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
