三种移植骨材料修复骨缺损能力的比较研究

目的 研究单纯异种无机骨，复合骨髓异种无机骨以及自体皮质骨修复骨缺损的能力。方法 取健康6月龄纯系新西兰大白兔22只，制作兔桡骨节段性骨缺损（1.5cm)模型。根据植入物的不同，随机分为自体皮质骨组（10肢），单纯异种无机骨组（10肢），复合骨髓的异种无机骨组（20肢）和空白对照组（4肢），术后2、4、6、8、12周进行放射线片和组织学观察。结果 单纯异种无机骨植入组，直至12周，仍为缓慢的骨传导过程，周边骨小梁向无机骨内爬行替代，异种无机骨内大部分为纤维组织，只有少数中心区域有新骨形成，而复合骨髓的异种无机骨植入后2周即有新骨形成，8周无机骨基本吸收替代完毕，12周髓腔形成，塑形改造，基本相关于自体皮质骨移植的融合速度，结论 复合骨髓的异种无机骨的成骨能力明显优于单纯异种无机骨，与自体皮质骨相当。

Comparative study on bone defect repair potentiality of three bone transplant materials

Objective:To study the ability bone defect repair of heterogenous inoganic bone, the compound of heterogenous inorganic bone and red bone marrow, autogenous bone Methods:22 rabbits were used (healthy,6-month,pure line,New Zealand large white rabbit)for this experimental study. 1.5cm bone defect model was made in each side of the radius. It was randomly divided into the implantation of autogenous bone group(10 forelegs),heterogenous inorganic bone group(10 forelegs), the compound of heterogenous inorganic bone and red bone marrow group(20 forelegs),and nothing as control group. Histological technique and x-ray examination were done after operation at 2,4,6,8,12 weeks. Results:In the group of heterogenous inorganic bone, the bone formation was still slow after 12 weeks,and the peripheral bone trabeculae were still devoid of creeping replacing into the inorganic bone and chiefly consisted of the fiberous tissues;and only in some small central areas there were some newly-formed bone. But in the group with compound bone of heterogenous inorganic bone and red bone marrow there was new bone formation and remodeling nearly similar to autogenous bone transplantation 12 weeks later. Conclusion:The bone formation ability of the compound of heterogenous inorganic bone and red bone marrow is obviously superior to heterogenous inorganic bone and similar to autogenous bone.