以生物电阻法检测的身体组成成分与女性骨量的关系

目的 探讨体内的体脂和非体脂对绝经前和绝经后妇女骨密度(BMD)的作用。方法 282例绝经前和205例绝经后妇女参加本研究,用双能X线骨密度仪测定腰椎和股骨颈BMD,用生物电阻法测定体脂和非体脂,同时测量身高、体重、腰围、臀围,并计算体重指数(BMI)和腰臀围比(WHR)。结果 体脂和非体脂与绝经前、绝经后妇女腰椎和股骨颈BMD均呈显著正相关(P＜0．01),多元逐步回归分析显示,在绝经前妇女中,非体脂和年龄是腰椎BMD的独立影响因素(R^2=0．077,P=0．000),非体脂、年龄和BMI是影响股骨颈BMD的决定因素(R^2=0．130,P=0．000),在绝经后妇女中,体脂和年龄是影响腰椎和股骨颈BMD的决定因素(R^2分别为0．153和0．184,P=0．000)。结论 体脂和非体脂对绝经前和绝经后妇女BMD的作用不同,非体脂是决定绝经前妇女骨量的重要因素,而体脂是影响绝经后妇女骨量的重要因素。

The relationship between body composition measured with bioelectric impedance analysis and bone mass in female

ObjectiveTo investigate the effect of fat mass and fat-free mass on bone mineral density(BMD) in pre- and postmenopausal women. Methods282 premenopausal women with regular menstruation and 205 postmenopausal women were enrolled in this study. BMD at lumbar spine (L_ 2-4) and femoral neck (FN) were measured with dual-energy X-ray absorptiometry(DEXA). Fat mass and fat-free mass were measured with bioelectric impedance analysis (BIA). Height,weight,waist and hip circumference were recorded. Body mass index (BMI) and waist hip ratio (WHR) were calculated. Results Fat mass and fat-free mass were significantly positively correlated with L_ 2-4 and FN BMD in both pre- and postmenopausal women ( P <0.01). Multiple regression analysis showed that in premenopausal women,fat-free mass and age were significant determinants of L_ 2-4 BMD (R 2=0.077, P =0.000),while fat-free mass,age and BMI were significant determinants of FN BMD (R 2=0.130,P =0.000). In postmenopausal women,fat mass and age were significant determinants of BMD at L_ 2-4 and FN (R 2 were 0.153 and 0.184 respectively,P =0.000). ConclusionsFat mass and fat-free mass have different effects on BMD in pre- and postmenopausal women. Fat-free mass is a significant determinant of BMD in premenopausal women,while fat mass contributes most to BMD in postmenopausal women.