丹参提取物对大鼠溃疡性结肠炎形态学变化的实验研究

目的探讨丹参提取物丹参素、丹参酮Ⅱ—A对溃疡性结肠炎(UC)大鼠模型形态学变化的影响。方法用5％乙酸经结肠灌注制备UC大鼠模型，分成正常组、模型组、丹参素组、丹参酮Ⅱ—A组及二者混合组、SASP组各10只。正常组、模型组每天灌服生理盐水10ml／kg，用药组分别每天灌服丹参素．和丹参酮Ⅱ—A及其混合液和SASP各1次，每次2ml。3周后处死。测定肠溃疡发生数、充血指数、肠重量、肠重指数、组织形态学评分。结果中、西药物组形态学变化均与模型组有明显差异，而与正常组无明显差异。结论丹参提取物可以显著治疗溃疡性结肠炎，有治疗UC的前景。

Experimental Studies on Distill of Danshen in the Change of Ulcerative Colitis Morphologic

Objective To investigate effects of Salvia Miltiorrhizae and Radix Salvia Miltiorrhizae on the change of ulcerative colitis (UC) morphologic.Methods Forty adult rats were randomly divided into four-groups: normal group,pattern group,ASP group,UC group.UC models were induced by 5% acetic acid in its colon.Normal group and UC group received 0.9% saline solution 10ml/kg/d,distill of danshen group and SASP group were fed separately distill of dance and SASP 2ml/d and the rats were killed after three weeks.Determining occur number,congest exponent,intestines weight,and intestines weight index,organize morphologic grade.Results Morphological index of distill of danshen group and SASP group were markedly different with that of UC group,not markedly different with normal group.Conclusions Distill of danshen can be markedly treated the UC group rats; it will be better to treat the disease Ulcerative Colitis.