高渗氯化钠羟乙基淀粉40用于失血性休克院前急救的临床观察

目的　观察高渗氯化钠羟乙基淀粉 4 0 (HS4 0 )对院前失血性休克的治疗作用 ,探索新的院前失血性休克容量复苏方法。方法　随“1 2 0”救护车外出 ,连续观察使用HS4 0对 4 4例失血性休克的治疗作用 ,分别测定用药前、用药后 30分钟、2、1 2、2 4小时的休克指数、平均动脉压、尿量 ,并与单用等渗羟乙基淀粉液对照和自身前后对照。结果　给药后平均动脉压和尿量比用药前明显增加 (P <0 .0 1～ 0 .0 5 ) ,30分钟和 2小时时相点显著高于对照组 (P <0 .0 5 ) ,2小时后相差不显著。给药后 ,各时相点休克指数比用药前明显降低 (P <0 .0 1～ 0 .0 5 ) ,并且 30分钟和 2小时时相点显著低于对照组 (P <0 .0 5 ) ,2小时后相差不显著 (P >0 .0 5 )。治疗组平均用药量和平均输入时间均低于对照组。结论　HS4 0对失血性休克的容量复苏有明显的治疗作用 ,并且优于单纯的羟乙基淀粉 ,有一定的临床应用价值

Therapeutic effect of hypertonic sodium chloride hydroxylethyl starch 40 on hemorrahagic shock in prehospital first aid

Objective To observe the therapeutic effect of hypertonic sodium chloride hydroxylethyl starch 40(HS40) on hemorrahagic shock. To probe a new therapeutic method on hemmorrahagic shock in prehospital first aid.Methods Forty four patients with hemorrahagic shock were observed and divided into 2 groups. Their shock index,mean arterial pressure and urine volume were measured before treatment and 30min,2h,12h,24h later and compared with those of the control group.Results The shock index decreased markedly and mean arterial pressure,urine volume were much higher at 30min,2h,12h,and 24h later(P<0.01). There was a significant difference between therapeutic and control groups at 30min and 2h.(P>0.05).Conclusion The effect of HS40 on hemorrahagic shock is significant and it may be valuable for clinical application.