丝裂原活化蛋白激酶激酶4与肿瘤转移

丝裂原活化蛋白激酶激酶4(MKK4)是丝裂原活化蛋白激酶(MAPK)信号转导通路组成的成员之一.研究发现,MKK4与肿瘤的发生和转移密切相关,作用机制复杂,能抑制肿瘤发生,近5%不同组织来源的肿瘤均有MKK4基因的功能突变缺失.MKK4基因也是一个转移抑制基因,能抑制多种肿瘤的转移.

Mitogen-activated protein kinase kinase 4 and tumor metastasis

Mitogen-activated protein kinase kinase 4(MKK4)is an important component of mitogenactivated protein kinase(MAPK)signaling conduction.It is highly related with tumors formation and metastasis,It is reported that loss of MKK4 gene functional mutations is found in approximately 5%of tumors of a variety of tissues,suggesting it may be a tumor suppresser gene.MKK4 also has been identified as a suppressor gene in tumors metastasis,which can suppress many tumors metastasis.