腰椎退行性变患者骨代谢变化与肾虚的关系

研究腰椎退行性变患者骨代谢变化与肾虚的关系。选择腰椎退行性变患者 75例 ,分为绝经前妇女组(15例 )、绝经后妇女组 (30例 )、成年男性组 (30例 ) ;正常人群 5 0例 ,分为三组 (15例、2 0例、15例 ) ,分别作为以上各组对照组。采用酶联免疫吸附法 (ELISA)分别测定各组血清骨钙素 (BGP)及尿Ⅰ型胶原交联C末端肽 (Cross laps)水平 ,对各组患者进行肾虚评分。结果 ,腰椎退行性变患者绝经后妇女组血清BGP水平高于对照组 (P <0 0 5 ) ,绝经前妇女组及成年男性组无此变化 (P >0 0 5 ) ;各组患者尿Crosslaps水平均高于相应对照组 (P <0 0 5 ,P<0 0 1,P <0 0 5 ) ,其中绝经后妇女组差异尤为显著 ;各组患者肾虚评分 ,绝经后妇女组分值最高 (与绝经前妇女组比较 ,P <0 0 1) ,其次是成年男性组 (与绝经前妇女组比较 ,P <0 0 5 )、绝经前妇女组 ,前两组之间无显著性差异 (P>0 0 5 )。腰椎退行性变患者均存在不同程度的肾虚及骨代谢紊乱表现 ,中医病机以肾虚为本 ,骨代谢紊乱可能是中医肾虚的重要改变之一

Relationship between Bone Metabolism and Kidney Deficiency in Degeneration of Lumbar Spine

Objective:To investigate the relationship between bone metabolic disturbance and kindey deficiency in degeneration of lumbar spine(DLS).Methods:75 patients with DLS were selected.According to sex and menopause condition,they were divided into three groups:premenopausal women group(15 cases),postmenopausal women group(30 cases) and adult men group(30 cases).50 healthy persons were selected and divided into corresponding control groups (15 cases,20 cases,15 cases).The levels of serum BGP and urine crosslaps were measured by ELISA.Meanwhile,all patients were graded according to kidney deficiency on syndrome differentiation of traditional Chinese medicine (TCM).Results:The serum BGM levels of postmenopausal patients with DLS were obviously higher than that of control group(P<0 05),but no significant differences existed on both premenopausal and adult men patients(P>0 05).The levels of crosslaps of all three patient groups were significantly higher than those of control groups( P <0 05, P <0 01,P<0 05).The scores of kidney deficiency on DLS,postmenopausal patient group and adult men patient group were higher than that of premenopausal patient group(P<0 01,P<0 05).There were no significant differences between postmenopausal patient group and adult men patient group(P>0 05).In DLS patients,to different extent,there was not only bone metabolism disturbance but also with DLS.Conclusions:To different extent,there was not only bone metabolism disturbance but also kidney deficiency apparence in three patient groups with DLS.Kidney deficiency was the main TCM pathogenesis of the disease.Bone metabolism disturbance may play an important role in kidney deficiency.