盐酸戊乙奎醚用作小儿氯胺酮全麻术前用药的效果

目的观察比较盐酸戊乙奎醚(phenehyclidime hydrochloride)和阿托品、东莨菪碱用作小儿未插管全麻手术术前用药的临床效果。方法45例小儿下腹部及四肢手术患者根据术前用药情况随机双盲分为盐酸戊乙奎醚组(phe组)、阿托品组(art组)和东莨菪碱组(sco组),各组15例,分别在麻醉开始前30min肌肉注射盐酸戊乙奎醚、阿托品、东莨菪碱0.01mg/kg,记录给药前(T0)及给药后10(T1)、30(T2)、60(T3)和120min(T4)患者的血压、心率、脉搏氧饱和度及患者面红、腺体分泌情况。结果三组患者年龄、性别、体重均无显著性差异(P>0.05);phe组术前注药后心率、血压无明显改变(P>0.05),art组、sco组注药后心率均明显增快(P<0.05),与phe组比较有显著性差异(P<0.05);phe组口干持续时间较atr、sco两组明显延长,与后两组比较,气管拔管时分泌物量明显减少,且面红发生率较低(P<0.05)。结论盐酸戊乙奎醚具有显著的心率稳定作用及强大持久的腺体分泌抑制作用,作为术前用药效果满意,优于阿托品和东莨菪碱,可安全用于小儿全麻醉手术术前给药。

Clinical study of penehyclidine hydrochloride as premedications of general anesthesia in children

Objective To investigate the clinical effects of penehyclidine hydrochloride used as premedication of general anesthesia for children and compare with atrop and scopomamine. Methods In a double-blinded,randomized study, 45 children patients were divided into three groups-group PHE (penehyclidine hydrochloride group, n=15), group ATR(atrop group, n=15) and group SCO(scopomamine group, n=15). Group PHE was injected muscularly with 0.02mg/kg penehyclidine hydrochloride 30 minutes before general anesthesia whil...