| 大剂量地塞米松及SOD在实验性脑损伤中的治疗作用 |
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| 引用本文： | 王锐,段国升.大剂量地塞米松及SOD在实验性脑损伤中的治疗作用[J].解放军医学杂志,1997,22(4):239-241. |
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| 作者姓名： | 王锐 段国升 |
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| 作者单位： | 海军总医院，解放军总医院 |
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| 摘 要： | 大剂量地塞米松和ＳＯＤ是外伤性脑继发性损害药物治疗的新方案。本实验在豚鼠局灶性脑损伤模型上试用该两种药物，通过脑含水量、灶周伊文斯兰渗出、血ＣＫ、Ｃａ和ＬＤＨ含室及光镜和电镜病理检查等指标。
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| 关 键 词： | 脑损伤 药物疗法 病理学 地塞米松 |
EXPERIMENAL STUDY OF HIGH DOSE DEXAMETHASONE AND SOD ON THE TREATMENT OF SECONDARY ACUTE BRAIN INJURY IN GUINEA PIGS |
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| Wang Rui,Duan Guosheng,Luo Yi et al.EXPERIMENAL STUDY OF HIGH DOSE DEXAMETHASONE AND SOD ON THE TREATMENT OF SECONDARY ACUTE BRAIN INJURY IN GUINEA PIGS[J].Medical Journal of Chinese People's Liberation Army,1997,22(4):239-241. |
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| Authors: | Wang Rui Duan Guosheng Luo Yi |
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| Institution: | Wang Rui,Duan Guosheng,Luo Yi et al. The Navy General Hospital of PLA,Beijing 100037 |
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| Abstract: | Both high dose dexamethone and SOD are new drugs for treating traumatic brain secondary damage. We tried to use them in the model of regional brain injury in Guinea pigs. The drug effects were assessed by measuring the brain water content,Evans blue extravasation and blood CK, Ca and LDH values, and the histopathological findings under the light and electron microscopes. The results showed that the effects of high dose dexamethasone and SOD groups were more effective than that of control groups, and the high dose dexamethasone group got better effects than the SOD group as compared with control group, and had statistical significance. |
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| Keywords: | brain injuries drug therapy pathology dexamethasone superoxide dismutase |
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