内皮细胞凋亡与勃起功能障碍的研究进展

勃起功能障碍(ED)是泌尿男科最常见的疾病之一,严重影响患者的生活质量,引起ED的因素包括衰老、糖尿病、高血压、高脂血症以及不良生活方式等,其确切机制尚未完全明确。目前随着对ED研究的不断深入,其中阴茎海绵体内皮细胞凋亡与ED的关系倍受关注,内皮细胞凋亡增加可引起NOS活性降低导致NO合成受阻,从而影响阴茎勃起,不同病因引起的ED其内皮细胞凋亡的机制不同。本文就阴茎海绵体内皮细胞凋亡在ED中的作用作一综述,对ED与内皮细胞凋亡机制的深入了解将为新药研制及其他治疗措施提供新的思路。

Endothelial cell apoptosis in erectile dysfunction

Erectile dysfunction(ED) is one of the most common male diseases,which seriously affects the patient's quality of life.The risk factors of ED include aging,diabetes,hypertension,hyperlipidemia,and unhealthy lifestyle,and its exact mechanism remains unclear.The apoptosis of endothelial cells in the corpus cavernosum penis may reduce NOS activity,block NO synthesis,and affect penile erection,and the mechanisms of their apoptosis vary with different causes of ED.This article updates the relationship between the apoptosis of endothelial cells and the development of ED.