运动负荷下去势雌性大鼠骨组织计量学和生物力学的改变

目的 探讨运动对去势大鼠骨代谢和生物力学性能的影响。方法 将４个月龄ＳＤ雌性大鼠４２只随机分成７组：正常组、模型组、运动组、服钙组、联合组、激素组和制动组。除正常组外，其余各组大鼠切除卵巢。检测各组大鼠骨密度（ＢＭＤ）、骨组织形态计量学和生物力学有关指标。结果 ⑴ＢＭＤ联合组０．３０６ｇ／ｃｍ＾２，运动组０．３０５ｇ／ｃｍ＾２，模型组０．２７５ｇ／ｃｍ＾２，制动组０．２５６ｇ／ｃｍ＾２。⑵骨组织形

The changes of bone histomorphometry and biomechanics in ovariectomized rat under exercise load

Objective\ To study the influence of exercise on bone histomorphometry and biomechanics in ovariectomized rat. Methods\ Forty-two SD female rats with 4 months old were divided into 7 groups: (1) normal control(N); (2)osteoporosis model(OVX); (3)exercise(Ex); (4)calcium intake(Ca); (5) Ex Ca; (6)extrogen(H) and (7)immobilization(I). The ovariotomy was performed in groups 2 to 7. Bone mineral density (BMD), histomorphometry and parameters of biomechanics were measured and analyzed. Results\ BMD in Ex Ca group and Ex group was 0.306*!g/cm 2 and 0.305*!g/cm 2 respectively, which was significantly higher than in OVX group(0.275*!g/cm 2). BMD in I group was the lowest (0.256*!g/cm 2) . Trabecular bone volume in N group, Ex group and Ex Ca group was 36.78 %, 30.33 % and 31.85 % without significant difference among them. Resorption surface in OVX group was 2.26 %, which was close to that in I group (2.25 %). Load fmax and maximal stress in Ex group and Ex Ca group were 129.6 N 130.6 N, and 169.5 N/mm 2 161.3 N/mm 2 respectively, which was higher than in N group (121.8 N and 152.9 N/mm 2 respectively). Conclusion\ Exercise could slower the loss of bone, keep the bone mass and improve the biomechanics nature of bone in ovarietomized rats.