不同时间注射咪唑安定防止全麻患者术中知晓的效果及对麻醉苏醒的影响

目的：研究在不同时间注射咪唑安定防止全麻患者术中知晓的效果及对苏醒时间的影响。 方法：选择45例胸腹部手术的全麻患者，随机分为对照组（C组）、D₁、D₂ 3组(每组15例)。用芬太尼、异丙酚和维库溴铵静脉注射诱导后行气管内插管。对照组不辅加镇静剂，D₁和D₂两组分别在诱导时和诱导30 min后注射咪唑安定。在脑电双频谱(BIS)保持同等状态下比较术中全麻药的用量及手术结束至拔气管导管时间。术后检验术中感知和回忆情况。 结果：加用咪唑安定避免全麻患者术中知晓效果优于对照组，诱导时注射咪唑安定预防术中知晓的效果优于诱导30 min后注射，麻醉苏醒所需时间短。 结论：与诱导同时注射咪唑安定效果最佳，且能减少全麻药用量，缩短麻醉苏醒时间，稳定病情。

Effects of Midazolam on preventing patients from awareness and reviving in different time with intravenous injection

Objective To study the effects of Midazolam on preventing patients underwent combined anesthesia from awareness and affect for regain consciousness in different time with intravenous injection (i.v). Methods 45 patients under went combined anesthesia were divided randomly into three groups(n=15): C,D1 and D2. These patients were induced and intubated with Fentanyl, Vercurium, Propofol iv. In group D1 Midazolam (i.v) was administrated in the meantime with induction, in group D2 Midazolam (i.v) after induction 30 min, while Midazolam was not administrated in group C. The anesthetic sum, time from operation and to extubation, awareness and recall were compared in C, D1, and D2 groups. Results It was beneficial to add Midazolam in combined anesthesia to avoid awareness and recall. The effects were different in refrain from awareness and affect for recovery time in the different time with i.v of Midazolam. Conclusion It was best that Midazolam (i.v) in the meantime with induction to prevent from awareness, reduce anesthetic sum, shorten the anesthesia recovery time and steady patient conditions.