凌晨3:00皮下注射短效胰岛素治疗2型糖尿病黎明现象

目的:观察应用凌晨3:00皮下注射短效胰岛素治疗2型糖尿病黎明现象的疗效。方法:对40例有黎明现象的2型糖尿病患者,使用短效胰岛素凌晨3:00注射4~6U。抽取肘静脉血测定空腹血糖(FPG)及早餐后2h血糖(2hPG),免疫比浊法测定糖化血红蛋白(HbA1c),比较治疗前后上述指标变化。结果:本组患者FPG从治疗前(9.5±1.6)mmol/L下降至(6.0±0.4)mmol/L,治疗2个月后仍保持为(5.6±0.4)mmol/L;2hPG从治疗前(13.8±0.8)mmol/L下降至(7.4±0.4)mmol/L,在治疗2个月后保持为(7.9±0.3)mmol/L;FPG和2hPG与治疗前比较,均具有显著性差异(P<0.01)。治疗2个月后,HbA1c从治疗前(8.3±0.6)%下降至(6.5±0.3)%,与治疗前比较,有显著性差异(P<0.01)。结论:短效胰岛素强化治疗黎明现象具有快速稳定的降血糖和降糖化血红蛋白作用。

Regular insulin inject treated the diabetic metabolism dawn phenomenon at 3:00 in the morning

Objective To observe the effects of regular insulin inject at 3:00 in the morning therapy diabetic metabolism dawn phenomenon (DMDP) patients. Method 40 DMDP patients were treated by regular insulin inject 4-6U at 3:00 in the morning. Fasting plasma glucose (FPG), 2 hours postprandial glucose (2hPG) and glycosylated hemoglobin A1c (GHbA1C) were tested before and after insulin therapy. Results After insulin therapy, FPG of patients reduced from (9.5±1.6)mmol/L(P<0.01)to (6.0±0.4)mmol/L, and maintained at (5.6±0.4)mmol/L at the 2 months follow-up.2hPG of patients reduced from (13.8±0.8)mmol/L(P<0.01)to (7.4 ± 0.4)mmol/L, and maintained at(7.9±0.3) at the 2 months follow-up.After 2 months, HbA1c reduced from(8.3±0.6)%(P<0.01) to (6.5±0.3)%. Conclusion Our research demonstrated that regular intensive insulin inject at 3:00 in the morning plays a role of fast glycemic controlled and reduces glycosylated hemoglobin A1c.