正交实验法评估伊曲康唑对甲真菌病的疗效

为了观察伊曲康唑治疗甲真菌病各种方法的疗效，探索服用该药的最低剂量和最佳治疗方案应用正交实验法观察４６例服用伊曲康唑的甲真菌病患者。结果显示：在４个观察组（１００ｍｇ每日１次，连续口服；１００ｍｇ，每日２次，隔周口服；２００ｍｇ，每日１次，隔周口服；２００ｍｇ，每日２次，每月服用１周）中，指甲时间最短的方法是：２００ｍｇ每日１次，隔周口服（平均治愈时间３．１１个月）；趾甲癣治疗时间最短的是：１００

Clinical observation on the therapeutic effect ofitraconazole to patient with onychomycosis by orthogonal method

To find the best regimen to treat patient with onychomycosis with itraconazole. The effect of itraconazole on patients with onychomycosis were observed and the data were analyzed by orthogonal method. The results showed that in fingernail groups, the best method is 200mg qd, a week per half month(cured in 3 11 months). In toenail groups, the best method is 100mg bid, a week per half month(cured in 3 70 months). The conclusions are the followings: The best methods of itraconazole on onychomycosis of fingernail and toenail are both: 100mg qd,a week per halfmonth. The prevalent method of large dosage is not better than the other three methods (P >0 05). In the 3 influential factors of the experiment, factor A(i.e. the interval of each period of the treatment) is the main factor. While the other two are equal to each other.