应激中述情障碍对唾液SlgA及Cor的影响

目的：探讨应激过程中述情障碍对唾液分泌型免疫球蛋白A（SIgA）及皮质醇（Cor）的影响。方法：60例高中男生为研究对象，应用多伦多述情障碍量表（TAS）评分（高分组A与低分组B），评定其心理状况；应用放免法测定应激前后唾液SIgA和Cor浓度的变化。所得数据用t检验和单因素相关分析进行评价。结果：（1）考试前1个月和考试当天，A组学生唾液SIgA浓度均低于B组（P均〈0．05）；2组学生考试当天SIgA值和考试前1个月类似（P均〉0．05）。（2）考试前1个月和考试当天，A组学生唾液Cor浓度均显著高于B组（P均〈0．05）；2组学生考试当天Cor浓度均高于考试前1个月（其中A组P〈0．01；B组P〈0．05）；（3）2组学生应激前后SIgA、Cor变化率差异显著（其中SIgA变化率P〈0．05；Cor变化率P〈0．01）；（4）TAS总分、因子Ⅰ、因子Ⅱ与考试前1个月SIgA值、Cor变化率均显著相关（P〈0．05）；因子Ⅲ和Cor变化率呈负相关（P〈0．05）；因子Ⅳ和各测量指标无显著相关（P〉0．05）。结论：应激和应激中述情障碍均可导致唾液SIgA及唾液Cor的改变。

The influence of alexithymia in stress on secretory IgA and cortisol in saliva

PURPOSE: To explore the influence of alexithymia in stress on secretory IgA (SIgA) and cortisol (Cor) in saliva. METHODS: 60 male students in high school were investigated and the psychological conditions were assessed by TAS (Group A was for high score and Group B for low score) and the change of the concentration of SIgA and Cor in saliva were examined by radio-immunoassay. All data was assessed by student's t test and single factor correlation analysis. RESULTS: (1) SIgA in Gr-A was significantly lower than that in Gr-B one month before examination and on the day of examination (P<0.05), and SIgA was similar in the two groups (P>0.05). (2) Cor in Gr-A was significantly higher than that in Gr-B one month before examination and on the day of examination (P<0.05). Cor in the two groups was significantly higher than on the day of examination one month before examination (Gr-A: P<0.01;Gr-B: P<0.05). (3) The change rate of SIgA and Cor in the two groups was significantly different before and after stress (SIgA:<0.05;Cor: P<0.01);(4) The total score of TAS, factor I and II were significantly correlated to the change rate of SIgA and Cor one month before examination (P<0.05);The factor III showed negative correlation to the change rate of Cor (P<0.05);The factor IV showed no significant correlation to the testing indexes (P>0.05). CONCLUSIONS: Stress and alexithymia in stress could result in the changes of SIgA and Cor in saliva. Supported by Science Fund of Education Bureau of Fujian Province (JA04206) and Science Fund of Fuzhou City (2004-69).