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Coumarinic Acid-Based Cyclic Prodrugs of Opioid Peptides that Exhibit Metabolic Stability to Peptidases and Excellent Cellular Permeability
Authors:Gudmundsson  Olafur S.  Pauletti  Giovanni M.  Wang  Wei  Shan  Daxian  Zhang  Huijuan  Wang  Binghe  Borchardt  Ronald T.
Affiliation:(1) Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, 66047;(2) Department of Chemistry, North Carolina State University, Raleigh, North Carolina, 27695;(3) Present address: Exploratory Biopharmaceutics and Drug Delivery, Bristol-Myers Squibb, Pharmaceutical Research Institute, One Squibb Drive, P.O. Box 191, New Brunswick, New Jersey, 08903-0191;(4) Present address: University of Cincinnati-Medical Center, P.O. Box 67004, Cincinnati, Ohio, 45267-0004;(5) Present address: Amgen, Thousand Oaks, California, 91320;(6) Present address: Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina, 27695
Abstract:
Keywords:esterase-sensitive prodrugs  peptide delivery  opioid peptides  Caco-2 cells  membrane permeability  chemical and enzymatic stability
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