| 幽门螺杆菌抑制大鼠乙酸胃溃疡愈合的机制 |
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| 引用本文： | 李成军,夏立丁,金丽,王国忠.幽门螺杆菌抑制大鼠乙酸胃溃疡愈合的机制[J].医学研究杂志,2009,38(8):28-29,F0003. |
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| 作者姓名： | 李成军 夏立丁 金丽 王国忠 |
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| 作者单位： | 齐齐哈尔医学院机能实验室,161006 |
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| 基金项目： | 黑龙江省普通高等院校骨干教师创新能力资助计划项目 |
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| 摘 要： | 目的 研究幽门螺杆菌抑制大鼠乙酸胃溃疡愈合的机制.方法 用幽门螺杆菌感染Wistar大鼠,4周后复制出乙酸胃溃疡模型,在溃疡模型复制后的3、8、16天测定胃窦部黏膜G细胞、D细胞的数目、胃液量和pH.结果 Hp+乙酸溃疡组G细胞数目、胃液量高于乙酸溃疡组(P<0.01);D细胞的数目和pH低于乙酸溃疡组(P<0.01).结论 幽门螺杆菌通过增加胃酸分泌抑制溃疡愈合.
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| 关 键 词： | 幽门螺杆菌 溃疡 胃酸分泌 |
Mechanism of Helicobacter Pylori Inhibiting the Healing of Acetic Acid-Induced Gastric Ulcer in Rats |
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| Li Chengjun,Xia Liding,Jin Li,Wang Guozhong.Mechanism of Helicobacter Pylori Inhibiting the Healing of Acetic Acid-Induced Gastric Ulcer in Rats[J].Journal of Medical Research,2009,38(8):28-29,F0003. |
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| Authors: | Li Chengjun Xia Liding Jin Li Wang Guozhong |
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| Abstract: | Objective To study the mechanism of Helicobacter Pylori inhibiting the healing of acetic acid - induced gastric ulcer in rats. Methods Rats were infected with Helicobacter Pylori and the model of acetic acid gastric ulcer was replicated at 4 weeks after in-fection. Amount of G cell and D cell in mucosa of gastric antrum, quantity of gastric juice and pH were measured at the 3rd,Sth, 16th day after the model was replicated. Results When the group of Hp + acetic acid ulcer compared with the group of acetic acid ulcer, the number of G cell, quantity of gastric juice increased (P < 0.01), and the number of D cell and pH decreased (P < 0.01). Conclusion Helicobacter Pylori inhibits ulcer healing through increasing gastric acid secretion. |
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| Keywords: | Helicobacter Pylori(HP) Ulcer Gastric acid secretion |
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