应用公式计算A型肉毒毒素剂量缓解脑瘫小腿三头肌痉挛的对照研究

目的探讨应用公式计算A型肉毒毒素(BTX-A)使用剂量是否可以提高疗效、延长疗效持续时间。方法15例脑瘫患儿为试验组,按照公式计算BTX-A使用剂量进行缓解痉挛治疗。58例患儿作为对照组,按常规方法确定BTX-A剂量。结果治疗后,试验组患儿下肢功能提高的幅度大于对照组(P<0.05),疗效持续时间显著长于对照组(P<0.001)。结论应用公式计算BTX-A剂量可以提高疗效,延长疗效持续时间。

Releasing Spasticity of Triceps Surae Muscle of Children with Spastic Cerebral Palsy by Botulinum Toxic A Block with Dose Calculated According to Certain Formula

Objective To investigate whether the curative effect of Botulinum Toxic A(BTX-A) block increased and prolonged when the dose calculated according to certain formula.Methods 15 children with cerebral palsy(CP) were appointed as the trial group and the dose of BTX-A was calculated according to the designed formula.The other 58 CP children were appointed as the control group and the BTX-A dose was determined by routine method.Results After treatment,the motor function of the children in trial group was superior to that in the control group(P<0.05) and the duration of therapeutic effect of the trial group was significantly longer than the control group(P<0.001).Conclusion BTX-A dose calculated according to the formula can increase effect and prolong the duration.