伴CRP增高的缺血性卒中患者相关危险因素Logistic回归分析

目的 探讨C-反应蛋白(C-reactive protein,CRP)增高的缺血性卒中(ischemic stroke,IS)患者的相关危险因素.方法 共纳入85例IS患者,且均证实CRP水平＞8 mg/L,同时从门诊随机抽取140例无动脉粥样硬化血管病史的人群作为对照组.采用免疫透射比浊法检测血清CRP水平.应用非条件Logistic回归分析进行多因素分析.结果 单因素分析结果表明:男性、高血压病史、冠心病病史、糖尿病史、吸烟史、饮酒史、家族卒中病史、入院首次收缩压、LDL与之呈正相关(P＜0.05)；生活规律及HDL与伴CRP增高的IS患者呈负 相关(P＜0.05)；两组间WBC差异存在显著性(均P＜0.05).进一步行多因素分析结果表明:男性、高血压病史、糖尿病史、吸烟史是伴CRP增高的IS患者的独立危险因素；而HDL是伴CRP增高的IS患者的保护因素.结论 伴CRP增高的IS患者的保护因素是HDL;其独立危险因素是男性、高血压病史、糖尿病史及吸烟史,其中男性、高血压病史及糖尿病史对伴CRP增高的IS患者的影响强度较大,对该类人群的高血压、糖尿病等危险因素进行必要的干预具有重要的意义.

Non-conditional logistic regression analysis on risk factors of CRP increasing in patients with ischemic stroke disease

【Objective】 The purpose of this study was to investigate the risk factors of increasing in CRP in patients with ischemic stroke(IS).【Methods】 85 hospitalized patients of IS with CRP>8 mg/L and 140 control subjects without clinical and instrumental evidence of atherosclerosis diseases were enrolled.All subjects were recorded traditional risk factors for IS and biochemistry indexes.Several statistically significant risk factors were screened out with univariate non-conditional logistic regression analysis,and then independent risk factors were determined with multivariate stepwise non-conditional logistic regression analysis.【Results】 Univariate non-conditional logistic regression analysis showed that man,hypertension history,heart disease history,diabetes history,smoking history,drinking history,stroke family history,admitting hospital SBP,LDL were positively correlated with increasing in CRP in patients with IS(P <0.05).The patterns of life and HDL were negatively correlated with increasing in CRP in patients with IS.Multivariate stepwise non-conditional logistic regression analysis showed that man,hypertension history,diabetes history and smoking were the independent risk factors of increasing in CRP in patients with IS.【Conclusion】 Man,hypertension history,diabetes history and smoking were independent risk factors of increasing in CRP in patients with IS.It is necessary to call for intervention treatment of increasing in CRP in patients with IS and its related risk factors in clinic.