| 固体制剂微环境pH测定技术研究进展 |
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| 引用本文： | 范云周,杨美燕,陈小平,高春生. 固体制剂微环境pH测定技术研究进展[J]. 中国新药杂志, 2012, 0(8): 867-872,883 |
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| 作者姓名： | 范云周 杨美燕 陈小平 高春生 |
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| 作者单位： | 军事医学科学院毒物药物研究所;北京嘉事联博医药科技有限公司 |
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| 基金项目： | 国家“重大新药创制”科技重大专项(2009ZX09301-002;2008ZXJ09010-001) |
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| 摘 要： | 目的:介绍近年来固体制剂微环境pH(pHM)测定技术的最新研究进展。方法:对已有文献进行综合、分析与归纳。结果:固体制剂pHM的测定存在较高的技术难度与要求,目前有酸碱指示剂法、微型及表面pH电极法、共聚焦激光扫描显微成像技术和电子顺磁共振成像技术等。结论:pHM测定技术可为pH调节剂的筛选和pHM调控技术作用机制研究提供重要参考指标。
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| 关 键 词： | 微环境 pH调节剂 微型pH电极 共聚焦激光扫描显微镜 电子顺磁共振成像 |
Advances in the measurement techniques of microenvironmental pH in solid dosage forms |
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| FAN Yun-zhou,YANG Mei-yan,CHEN Xiao-ping,GAO Chun-sheng. Advances in the measurement techniques of microenvironmental pH in solid dosage forms[J]. Chinese Journal of New Drugs, 2012, 0(8): 867-872,883 |
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| Authors: | FAN Yun-zhou YANG Mei-yan CHEN Xiao-ping GAO Chun-sheng |
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| Affiliation: | 1,2(1 Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China; 2 Beijing JIASHILIANBO Pharmaceutical Sci.& Tech Co.,Ltd.,Beijing 100076,China) |
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| Abstract: | Objective: To review the recent advances in the measurement techniques of microenvironmental pH(pHM) in solid dosage forms.Methods: The published reports were analyzed and summarized.Results: It is rather difficult to determine the pHM in solid dosage forms.The pH indicator,pH microelectrode,surface pH electrode,confocal laser scanning microscopy,and electron paramagnetic resonance imaging methods have been used in recent years.Conclusion: The measurement techniques of pHM are very important for the selecting of pH modifiers and the mechanism investigating of pHM modified technology. |
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| Keywords: | microenvironmental pH modifier pH microelectrode confocal laser scanning microscopy electron paramagnetic resonance imaging |
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