2型糖尿病视网膜病变患者血脂谱分析 |
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引用本文: | 孟健,徐凌,俞春芳,顾庆,房静娴,李静怡,王华荣,葛军. 2型糖尿病视网膜病变患者血脂谱分析[J]. 中国慢性病预防与控制, 2012, 20(1): 41-43 |
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作者姓名: | 孟健 徐凌 俞春芳 顾庆 房静娴 李静怡 王华荣 葛军 |
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作者单位: | 上海市杨浦区市东医院 内分泌科,200438 |
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基金项目: | 上海市杨浦区青年课题基金资助项目(200809) |
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摘 要: | 目的了解2型糖尿病视网膜病变患者血脂谱的变化及其与糖尿病视网膜病变(DR)发生的关系。方法选取2型糖尿病患者224例,分为无视网膜病变(NDR)组110例,DR组114例。进行血脂和糖化血红蛋白等生化指标的检测,分析两组患者间病程、糖化血红蛋白及各项血脂指标与视网膜病变的相关性。结果在各项血脂指标中,DR组载脂蛋白B(ApoB)、脂蛋白(a)[Lp(a)]高于NDR组,而载脂蛋白A(ApoA)/ApoB低于NDR组,两组差异有统计学意义(P<0.05)。多因素非条件Logistic回归分析显示,DR的发生与Lp(a)水平(OR=1.30,95%CI:1.01~1.67),ApoA/ApoB(OR=0.54,95%CI:0.33~0.87)及病程(OR=1.73,95%CI=1.30~2.30)相关联。结论 Lp(a)及ApoA/ApoB等血脂异常可能是DR的危险因素之一,积极地纠正血脂紊乱有利于糖尿病视网膜病变的防治。
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关 键 词: | 糖尿病,2型 糖尿病视网膜病变 血脂谱 |
Analysis on Blood Lipid Profile in Type 2 Diabetes with Retinopathy |
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Affiliation: | MENG Jian,XU Ling,YU Chun-fang,et al.Department of Endocrinology,Shidong Hospital,Shanghai 200438,China |
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Abstract: | Objective To analyze the changes in blood lipid profile in type 2 diabetes with retinopathy,and the relationship with diabetic retinopathy(DR).Methods 224 patients with type 2 diabetes were divided into a group without retinopathy(NDR)(110 patients)and a DR group(114 patients).To analyze the correlation between disease course,HbA1C,blood lipid indices and DR.Results The levels of ApoB and Lp(a)in the DR group were higher than those in the NDR group(P<0.05),while the ratio of ApoA/ApoB was lower than that in the NDR group(P<0.05).Logistic regression analysis showed that the incidence of retinopathy was correlated with Lp(a)(OR=1.30,95%CI:1.01~1.67),ApoA /ApoB(OR=0.54,95%CI:0.33~0.87)and disease course(OR=1.73,95%CI:1.30~2.30).Conclusion The Lp(a)and ApoA /ApoB might be the risk factors of DR.To monitor the lipid profile and actively correct the dyslipidemia might be benefit to the prevention and treatment of DR. |
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Keywords: | Diabetes mellitus,type 2 Diabetic retinopathy Blood lipid profile |
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