电离辐射诱导G2期阻滞的机制

电离辐射损伤后,细胞通过若干关卡来调控细胞周期的进程,使细胞有时间进行DNA修复,确保染色体组的完整性和遗传稳定性,减少突变的发生。不同的电离辐射使不同细胞产生G1、G2和S期等不同时相的变化,但电离辐射后G2期阻滞的现象十分普遍。近年来,对G2期阻滞机制的研究多集中在Chk1、Chk2和p53上。

Mechanisms of ionizing radiation-induced G2 arrest

Cells regulate cell cycle progression by arresting several checkpoints in response to ionizing radiation,which provides time for them to repair DNA damage,ensures genomic integrity and genetic stability and in turn decreases genetic mutations.Different cells arrest different checkpoints such as G 1 -,G 2 -and S-phase checkpoint in response to different ionizing radiations,whereas G 2 -phase arrest is more prevalent.More attention has been focused on Chk1,Chk2and p53in the study of mechanisms of ionizing-radiation-induced G 2 arrest these years.