Clear-cell ependymoma of the cerebellum: a case report |
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Authors: | Kim Ji Hoon Cho Byung-Kyu Kim In-One Park Sung-Hye |
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Institution: |
a Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
b Department of Pediatric Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea
c Department of Pediatric Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea
d Neuroscience Research Institute, Seoul National University, Seoul, Republic of Korea |
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Abstract: | A case of clear-cell ependymoma occurring in the cerebellum of a 3-year-old girl is reported. Light-microscopically, the tumor consisted mainly of clear cells with a perinuclear halo and showed some vague perivascular pseudorosettes, not true rosettes. In addition, the histological features of anaplasia, characterized by increased mitosis and focal pseudopalisading necrosis, were also observed. Immunohistochemically, the tumor cells were focally positive for glial fibrillary acidic protein and weakly positive for epithelial membrane antigen. Ultrastructurally, the intermediate junctions and rudimentary cilia confirmed the ependymal differentiation. Fifteen cases of infratentorial clear-cell ependymoma have been reported to date, and this case is the second childhood tumor among them, to the best of the authors' knowledge. |
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Keywords: | cerebellum child clear cell ependymoma immunohistochemistry ultrastructure |
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