曲美布汀、谷维素、山茛菪碱联合治疗老年人肠易激综合征疗效观察

目的观察曲美布汀、谷维素、山茛菪碱联合治疗老年人肠易激综合征（IBS）的临床效果。方法80例IBS患者随机分为对照组32例和观察组48例，对照组采用曲美布汀治疗，观察组采用曲美布汀、谷维素、山茛菪碱等联合治疗，比较两组治疗效果及治疗后症状评分。结果经治疗后，观察组症状显著改善31例（64．6％）、症状有效改善13例（27．1％）、症状元改善者4例（8．3％）、症状总改善率为91．7％；对照组分别为9例（28．1％）、12例（37．5％）、11冽（34．4％）、65．6％。两组症状显著改善率及症状总改善率差异有统计学意义（χ2=10．21、8．54，均P〈0．05）。观察组症状程度评分（1．52±0．45）分、症状频率评分（1．75±0．55）分，对照组分别为（2．57±0．58）分、（2．55±0．35）分，两组差异有统计学意义（t=9．10、7．29，均P〈0．05）。结论曲美布汀、谷维素及山莨菪碱联合治疗IBS效果好，且较为安全。

Clinical research on trimebutine maleate,oryzanol and anisodamine combined application in treatment of the elderly patients with irritable bowel syndrome

Objective To explore more effective treatments for irritable bowel syndrome(IBS)in old people.Methods 80 patients with irritable bowel syndrome were selected.adverse drug reaction during treatment,and therapy effect of a symptom score after treatment observation group and control group were compared.Results Total improvement rate of symptoms from observation group was 91.7％,and total improvement rate of symptoms in control group was 65.6％.Difference of proportions of significant improvement and improvement was significant,according to the situation that was controlled between observation group and control group.The difference of symptom score after treatment was significant,according to the situation that was controlled between observation group and control group.Conclusion Trimebutine maleate,oryzanol and anisodamine combined application could remarkably improve irritable bowel syndrome treatment effect,and was more safe.