尼莫地平对脑出血后脑损害的保护作用研究

目的研究尼莫地平对脑出血后脑损害的保护作用。方法62例脑出血后脑损伤患者随机分成两组，每组31例，对照组采用常规方法治疗，治疗组在对照组基础上采用尼莫地平治疗，疗程为10d。比较治疗前后两组患者的神经功能缺损评分、血肿体积、临床有效率。结果治疗后，两组患者神经缺损评分均显著降低，治疗组下降更明显（P〈0．05）；两组患者血肿体积明显缩小，治疗组更明显（P〈0．05）；对照组总有效率为51．6％，治疗组总有效率为77．4％，两组差异有统计学意义（P〈0．05）。结论尼莫地平对脑出血后脑损伤具有明显的保护作用，可改善神经功能，缩小血肿体积。

The protective effect of Nimodipine treatment of brain damage in patients with cerebral hemorrhage

Objective To study the protective effect of Nimodipine treatment of brain damage in patients with cerebral hemorrhage.Methods 62 cases of brain damage in patients with cerebral hemorrhage were divided into treatment group and control group,each for 31 cases.The control group were given conventional treatment,and the treatment group were given Nimodipine on the basis of the control group,treatment for 10d.NIHSS,hematoma volume and clinical effective rate were compared.Results After treatment,the NIHSS was lower between two groups,the treatment group decline was more obvious(P ＜ 0.05).The hematoma volume was decreased,the treatment group decrease was more obvious(P ＜0.05).The total effective rate was 51.6％ in the control group,and the total effective rate was 77.4％.There were significantly statistical differences between two groups(P ＜ 0.05).Conclusion Nimodipine had a protective effect for brain damage in patients with cerebral hemorrhage,and could improve the nervous function and decrease hematoma volume,and it was a reliable drug.