左卡尼汀对促红细胞生成素治疗血液透析患者肾性贫血疗效的影响

目的 探讨左卡尼汀对促红细胞生成素治疗血液透析患者肾性贫血疗效的影响.方法 将40例进行血液透析治疗（HD）的慢性肾衰尿毒症患者,随机分为治疗组和对照组,每组20例.对照组给予促红细胞生成素9 000 u/周,于血液透析后皮下注射,同时常规口服铁剂、叶酸.治疗组在对照组基础上予左卡尼汀1.0g加入20 ml 0.9％氯化钠注射液静脉缓慢注射3～5 min,每周2次.两组均治疗3个月.治疗前和治疗4周、3个月后检测血红蛋白（Hb）、血细胞比容（Hct）、血清铁蛋白（SF）、血清全段甲状旁腺素（iPHT）并比较.结果 治疗组治疗4周后,Hb、Hct水平较治疗前上升（均P＜0.05）.3个月后两组Hb较治疗前均显著升高（均P＜0.05）,而且治疗组Hb的升高明显优于对照组（P＜0.01）.结论 左卡尼汀能提高促红细胞生成素治疗血液透析患者肾性贫血的疗效.

Influence of L-carnitine on the effect of erythropoietin in treatment of patients with renal anemia during hemodialysis treatment

Objective To explore the influence of L-carnitine on the effect of erythropoietin in treatment of patients with renal anemia during hemodialysis treatment.Methods 40 uremic patients with chronic renal failure underwent bemodialysis(HD) in were randomly divided into treatment group and control group,20 cases each.Control group was given EPO 9000u/week subcutaneous injection in the blood after dialysis,while regular oral iron,folic acid.Treatment group on the basis of the control group to 1.0g L-carnitine added 20ml 0.9％ sodium chloride injection intravenously 3 ～ 5 min,2 times per week.Both groups were treated for 3 months.Before treatment and after 4 weeks and 3 months treatment.The hemoglobin(Hb),hematocrit (Hct),serum ferritin (SF),serum thyroxine(iPHT) and compared.Results After 4 weeks of treatment,Hb,Hct levels increased compared with before treatment( all P ＜0.05).Hb after 3 months compared with the two groups before treatment were significantly higher(all P ＜0.05),and Hb increase of the treatment group significantly higher than the control group ( P ＜ 0.01).Conclusion L-carnitine could improve the treatment of erythropoietin in hemodialysis patients with renal anemia.