Tumorigenesis in the brain: location, location, location |
| |
Authors: | Gilbertson Richard J Gutmann David H |
| |
Affiliation: | Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. Richard.Gilberston@stjude.org |
| |
Abstract: | Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties ("cancer stem cells"). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|