| 壳寡糖促进岩黄连总碱提取物中原小檗碱型生物碱成分肠道吸收的研究 |
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| 引用本文： | 李昕阳,谢辉,陆兔林,史月姣,张兴德,刘婷. 壳寡糖促进岩黄连总碱提取物中原小檗碱型生物碱成分肠道吸收的研究[J]. 中国中药杂志, 2015, 40(9): 1812-1816 |
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| 作者姓名： | 李昕阳 谢辉 陆兔林 史月姣 张兴德 刘婷 |
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| 作者单位： | 南京中医药大学, 江苏 南京 210023,南京中医药大学, 江苏 南京 210023,南京中医药大学, 江苏 南京 210023,南京中医药大学, 江苏 南京 210023,南京中医药大学, 江苏 南京 210023,南京中医药大学, 江苏 南京 210023 |
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| 基金项目： | 江苏高校优势学科建设工程项目 |
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| 摘 要： | 目的 :考察壳寡糖对岩黄连总碱提取物中原小檗碱型生物碱活性成分肠道吸收的促进作用. 方法 :采用大鼠在体肠单向灌流模型,研究添加不同浓度壳寡糖后岩黄连总碱中脱氢卡维丁、盐酸小檗碱和盐酸巴马汀的吸收动力学参数变化,评价壳寡糖对药物成分肠道吸收的促进作用. 结果 :壳寡糖的浓度对3个活性指标成分在大鼠肠道的吸收速率常数(Ka)和有效渗透系数(Peff)具有不同程度的影响,在0.5%壳寡糖溶液中活性指标成分的Ka和Peff增加明显,呈现较强的吸收促进作用. 结论 :壳寡糖对岩黄连生物碱中原小檗碱型生物碱活性成分的肠道吸收有一定促进作用.
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| 关 键 词： | 壳寡糖 岩黄连总碱 脱氢卡维丁 盐酸小檗碱 盐酸巴马汀 在体肠灌流法 |
| 收稿时间： | 2014-10-22 |
Study on effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids |
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| LI Xin-yang,XIE Hui,LU Tu-lin,SHI Yue-jiao,ZHANG Xing-de and LIU Ting. Study on effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids[J]. China Journal of Chinese Materia Medica, 2015, 40(9): 1812-1816 |
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| Authors: | LI Xin-yang XIE Hui LU Tu-lin SHI Yue-jiao ZHANG Xing-de LIU Ting |
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| Affiliation: | Nanjing University of Chinese Medicine, Nanjing 210023, China,Nanjing University of Chinese Medicine, Nanjing 210023, China,Nanjing University of Chinese Medicine, Nanjing 210023, China,Nanjing University of Chinese Medicine, Nanjing 210023, China,Nanjing University of Chinese Medicine, Nanjing 210023, China and Nanjing University of Chinese Medicine, Nanjing 210023, China |
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| Abstract: | Objective:To investigate the effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids. Method:The in vitro single-pass intestinal perfusion model in rats was established to study the changes in absorption kinetic parameters of dehydrocavidine, berberine hydrochloride and palmatine chloride in C. saxicola total alkaloids after the addition of different concentrations oligochitosan and evaluate the effect of oligochitosan in promoting intestinal absorption of the drugs. Result:The concentration of oligochitosan had different effects on the absorption rate constant (Ka) and apparent permeability coefficient (Peff) of the three active component in rat intestines. Ka and Peff in 0.5% oligochitosan group significantly increased, indicating a stronger effect in promoting the absorption. Conclusion:Oligochitosan has a certain effect in promoting the intestinal absorptions of protoberberine alkaloids in C. saxicola total alkaloids. |
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| Keywords: | oligochitosan the alkaloids of Yanhuanglian dehydrocavidine berberine hydrochloride palmatine hydrochloride in vitro single-pass intestinal perfusion |
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