甲氨蝶呤联合来氟米特治疗类风湿关节炎的疗效

目的探讨甲氨蝶呤联合来氟米特治疗类风湿关节炎（RA）患者的临床疗效。方法将80例RA患者随机分为两组,治疗组采用甲氨蝶呤联合来氟米特进行治疗,对照组采用甲氨蝶呤联合羟氯喹进行治疗;观察疗效和治疗前及治疗后1、2、3、4月的抗环瓜氨酸肽抗体（ACCP）、C反应蛋白（CRP）和类风湿因子（RF）的变化。结果治疗2月后,两组之间的总有效率差异有统计学意义（P〈0.05）;治疗2、3、4个月时,治疗组的的ACCP、CRP和RF均明显低于对照组（P〈0.05）。结论甲氨蝶呤与来氟米特联合用药能有效地治疗RA,对RA患者的ACCP、CRP和RF水平降低程度显著,有效控制病情,为临床治疗RA提供依据。

Curative effect of methotrexate combined with leflunomide in treatment of rheumatoid arthritis

Objective]To explore clinical curative effect of methotrexate combined with leflunomide in treatment of patients with rheumatoid arthritis（ RA）.Methods]80 RA patients were randomly divided into two groups. The treatment group was treated with methotrexate combined with leflunomide,and the control group was given methotrexate combined with hydroxychloroquine. The curative effect was observed. The levels of ACCP,RF and CRP before treatment,and 1,2,3 and 4 month after treatment were analyzed.Results]After 2 months of treatment,there was significant difference in the total effective rate between two groups（ P〈0. 05）. At the end of 2,3 and 4 months after treatment,the levels of ACCP,RF and CRP in the treatment group were significantly lower than those in the control group（ P〈0. 05）.Conclusion]The methotrexate combined with leflunomide has significant curative effect in RA patients,which can obviously reduce the levels of ACCP,RF and CRP,effectively control the disease condition,and provide a basis for clinical treatment of RA.