| 肿瘤新生血管生成抑制剂的研究进展 |
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| 引用本文： | 萧东,丁健.肿瘤新生血管生成抑制剂的研究进展[J].中国新药杂志,2001,10(4):248-251. |
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| 作者姓名： | 萧东 丁健 |
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| 作者单位： | 中国科学院上海药物研究所, |
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| 基金项目： | 国家重大基础研究规划项目(973)资助(G1998051104) |
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| 摘 要： | 肿瘤血管生成柳制剂一类能破坏或抑制血管生成，有效地阻止肿瘤生长和转移的药物。按作用机制可分为5大类：①抑制基底膜降解。②直接抑制内皮细胞增殖。③抑制血管生长因子活化。④抑制内皮细胞特异性整合素／生存信号。⑤其他非特异性作用机制的药物。本文主要简介正在进行临床试验的肿瘤血管生成抑制剂的最新研究进展。
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| 关 键 词： | 肿瘤新生血管生成抑制剂 抗肿瘤药物 |
| 文章编号： | 1003-3734(2001)04-0248-04 |
Progress in development of tumor angiogenesis inhibitors |
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| XIAO Dong,DING Jian.Progress in development of tumor angiogenesis inhibitors[J].Chinese Journal of New Drugs,2001,10(4):248-251. |
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| Authors: | XIAO Dong DING Jian |
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| Abstract: | Tumor angiogenesis inhibitor is a class of new drugs that can destroy or inhibit tumor neovascularization,and can effectively block the growth and metastasis of cancer.It may be divided into five categories according to their mechanisms of action:class 1,drugs that block basement membrane breakdown;class 2,drugs that directly inhibit the growth of endothelial cell;class 3,drugs that block the activation of angiogenesis factor;class 4,drug that inhibit endothelial-specific integrin/survival signaling;and class 5,drugs with non-specfic mechanism of action.The main aim of this paper is to introduce the latest development in angiogenesis inhibitors that are undergoing clinical trials. |
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| Keywords: | tumor angiogenesis inhibitor |
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